反应条件
1: 1.) O3, 2.) Me2S, Et3N / 1.) MeOH, CH2Cl2, -78 deg C, 2.) room temp., 1 h 2: NaClO2, NaH2PO4*H2O / various solvent(s); 2-methyl-propan-2-ol; H2O / 1.) 0 deg C, 30 min, 2.) room temp., 3 h 3: 48percent HF / acetonitrile; CH2Cl2 / 4 h 4: 1.) LDA / 1.) THF, -50 deg C, 40 min; -30 deg C, 40 min, 2.) HMPA, -50 deg C, 1 h; -20 deg C, 2 h; 0 deg C, 1 h 5: 1 N KOH / ethanol / 4 h / 50 °C 6: benzenesulfonyl chloride, pyridine / 0 °C 7: H2 / 10percent Pd-C / ethyl acetate View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 27 p. 7768 - 7781
