[5-(羟基甲基)-2-萘基]-氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
sodium tetrahydroborate in ethanol
T=20°C; 2 h;
参考文献
Gopalsamy, Ariamala; Lim, Kitae; Ellingboe, John W.; Mitsner, Boris; Nikitenko, Antonia; Upeslacis, Janis; Mansour, Tarek S.; Olson, Matthew W.; Bebernitz, Geraldine A.; Grinberg, Diane; Feld, Boris; Moy, Franklin J.; O'Connell, John
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1893 - 1899
反应条件
1.1: pyridine / dimethylformamide / 6 h / 160 °C
2.1: aq. NaOH / methanol / 20 °C
3.1: 4.2 g / Et3N; phosphorazidic acid diphenyl ester / 72 h
4.1: pyridine / acetic acid / 0.5 h
4.2: 2.71 g / Raney Ni; pyridine / acetic acid / 1.5 h / 46 °C
5.1: NaBH4 / ethanol / 2 h / 20 °C
View Scheme
参考文献
Gopalsamy, Ariamala; Lim, Kitae; Ellingboe, John W.; Mitsner, Boris; Nikitenko, Antonia; Upeslacis, Janis; Mansour, Tarek S.; Olson, Matthew W.; Bebernitz, Geraldine A.; Grinberg, Diane; Feld, Boris; Moy, Franklin J.; O'Connell, John
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1893 - 1899
反应条件
1.1: 3.82 g / HCl(g) / 5 h / Heating
2.1: pyridine / dimethylformamide / 6 h / 160 °C
3.1: aq. NaOH / methanol / 20 °C
4.1: 4.2 g / Et3N; phosphorazidic acid diphenyl ester / 72 h
5.1: pyridine / acetic acid / 0.5 h
5.2: 2.71 g / Raney Ni; pyridine / acetic acid / 1.5 h / 46 °C
6.1: NaBH4 / ethanol / 2 h / 20 °C
View Scheme
参考文献
Gopalsamy, Ariamala; Lim, Kitae; Ellingboe, John W.; Mitsner, Boris; Nikitenko, Antonia; Upeslacis, Janis; Mansour, Tarek S.; Olson, Matthew W.; Bebernitz, Geraldine A.; Grinberg, Diane; Feld, Boris; Moy, Franklin J.; O'Connell, John
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1893 - 1899
反应条件
1.1: 4.2 g / Et3N; phosphorazidic acid diphenyl ester / 72 h
2.1: pyridine / acetic acid / 0.5 h
2.2: 2.71 g / Raney Ni; pyridine / acetic acid / 1.5 h / 46 °C
3.1: NaBH4 / ethanol / 2 h / 20 °C
View Scheme
参考文献
Gopalsamy, Ariamala; Lim, Kitae; Ellingboe, John W.; Mitsner, Boris; Nikitenko, Antonia; Upeslacis, Janis; Mansour, Tarek S.; Olson, Matthew W.; Bebernitz, Geraldine A.; Grinberg, Diane; Feld, Boris; Moy, Franklin J.; O'Connell, John
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1893 - 1899
反应条件
1.1: aq. NaOH / methanol / 20 °C
2.1: 4.2 g / Et3N; phosphorazidic acid diphenyl ester / 72 h
3.1: pyridine / acetic acid / 0.5 h
3.2: 2.71 g / Raney Ni; pyridine / acetic acid / 1.5 h / 46 °C
4.1: NaBH4 / ethanol / 2 h / 20 °C
View Scheme
参考文献
Gopalsamy, Ariamala; Lim, Kitae; Ellingboe, John W.; Mitsner, Boris; Nikitenko, Antonia; Upeslacis, Janis; Mansour, Tarek S.; Olson, Matthew W.; Bebernitz, Geraldine A.; Grinberg, Diane; Feld, Boris; Moy, Franklin J.; O'Connell, John
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1893 - 1899
反应条件
1.1: pyridine / acetic acid / 0.5 h
1.2: 2.71 g / Raney Ni; pyridine / acetic acid / 1.5 h / 46 °C
2.1: NaBH4 / ethanol / 2 h / 20 °C
View Scheme
参考文献
Gopalsamy, Ariamala; Lim, Kitae; Ellingboe, John W.; Mitsner, Boris; Nikitenko, Antonia; Upeslacis, Janis; Mansour, Tarek S.; Olson, Matthew W.; Bebernitz, Geraldine A.; Grinberg, Diane; Feld, Boris; Moy, Franklin J.; O'Connell, John
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1893 - 1899
