DL-ALPHA-(甲胺基甲基)苄醇合成路线 （共 40 条）
反应条件
1: 1.) t-BuLi / 1.) THF, -78 deg C; -78 deg C -> room temperature, 1 h; 2.) -78 deg C
2: MeOH-H2O / 15 h / 20 °C
3: MeOH-H2O / 18 h / Heating
View Scheme
参考文献
Meyers, A. I.; Hoeve, Wolter Ten
Journal of the American Chemical Society, 1980 , vol. 102, # 23 p. 7125 - 7126
反应条件
2: KOH / xylene / 4 h / Heating
3: aq. HCl / butan-2-one
View Scheme
参考文献
Dillard,R.D.; Easton,N.R.
Journal of Organic Chemistry, 1966 , vol. 31, p. 122 - 127
反应条件
methanol; water
18 h; Heating; Yield given;
参考文献
Meyers, A. I.; Hoeve, Wolter Ten
Journal of the American Chemical Society, 1980 , vol. 102, # 23 p. 7125 - 7126
反应条件
sodium hydroxide; hydrogen; palladium on activated charcoal in ethanol
参考文献
Amschler; Schultz
Arzneimittel-Forschung, 1972 , vol. 22, # 12 p. 2095 - 2096
反应条件
1: (i) Br2, AcOH, (ii) Al(OiPr)3, iPrOH, (iii) /BRN= 741851/
2: H2, aq. NaOH / Pd-C / ethanol
View Scheme
参考文献
Amschler; Schultz
Arzneimittel-Forschung, 1972 , vol. 22, # 12 p. 2095 - 2096
反应条件
hydrogenchloride in butanone
参考文献
Dillard,R.D.; Easton,N.R.
Journal of Organic Chemistry, 1966 , vol. 31, p. 122 - 127
反应条件
1: formaldehyd; 2-hydroxy-2-phenylethanamine
2: With sodium tetrahydroborate
参考文献
Joubert, Jerome; Roussel, Solveig; Christophe, Carole; Billard, Thierry; Langlois, Bernard R.; Vidal, Thierry
Angewandte Chemie - International Edition, 2003 , vol. 42, # 27 p. 3133 - 3136
反应条件
1: 57 percent / K2CO3 / acetone / 48 h / Heating
2: 97 percent / NaBH4 / ethanol / 12 h
View Scheme
参考文献
Nordlander, Eric J.; Payne, Mark J.; Njoroge, George F.; Balk, Michael A.; Laikos George D.; Vishwanath, Vasanth M.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4107 - 4111
反应条件
1: KOH / xylene / 4 h / Heating
2: aq. HCl / butan-2-one
View Scheme
参考文献
Dillard,R.D.; Easton,N.R.
Journal of Organic Chemistry, 1966 , vol. 31, p. 122 - 127
反应条件
sodium tetrahydroborate in methanol
参考文献
Sadet; Lipszyc; Chenu; et al.
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 277 - 288
