DL-ALPHA-(甲胺基甲基)苄醇合成路线 （共 40 条）
反应条件
1.1: CrO3; aq. H2SO4 / 2 h / 40 °C 1.2: 62 percent / NaNO2 / CH2Cl2 / 20 °C 2.1: 84 percent / NaOH; Na2CO3 / dimethylformamide / 1.25 h / 25 °C View Scheme
参考文献
Saavedra, Joseph E.; Farnsworth, David W.
Organic Preparations and Procedures International, 1991 , vol. 23, # 2 p. 139 - 146
反应条件
1.1: CrO3; aq. H2SO4 / 2 h / 40 °C 1.2: 62 percent / NaNO2 / CH2Cl2 / 20 °C 2.1: 84 percent / NaOH; Na2CO3 / dimethylformamide / 1.25 h / 25 °C 3.1: aluminum-copper alloy; aq. KOH / methanol / 24 h / 25 °C View Scheme
参考文献
Saavedra, Joseph E.; Farnsworth, David W.
Organic Preparations and Procedures International, 1991 , vol. 23, # 2 p. 139 - 146
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; Hydrolysis; 12 h;
参考文献
Alonso, Diego A.; Alonso, Emma; Najera, Carmen; Ramon, Diego J.; Yus, Miguel
Tetrahedron, 1997 , vol. 53, # 13 p. 4835 - 4856
参考文献
Roth; Brandau
Archiv der Pharmazie (Weinheim, Germany), 1959 , vol. 292, p. 761,769, 775
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=70 - 75°C; 8 h;
参考文献
Moehre, H.; Kamper, Ch.
Pharmazie, 1983 , vol. 38, # 8 p. 512 - 520
反应条件
hydrogenchloride in methanol; water
1.5 h; Reflux;
参考文献
Moshkin, Vladimir S.; Sosnovskikh, Vyacheslav Ya.
Tetrahedron Letters, 2013 , vol. 54, # 44 p. 5869 - 5872
反应条件
sodium tetrahydroborate in ethanol
12 h;
参考文献
Nordlander, Eric J.; Payne, Mark J.; Njoroge, George F.; Balk, Michael A.; Laikos George D.; Vishwanath, Vasanth M.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4107 - 4111
反应条件
water; nickel
T=90°C; P=36775.4 Torr; Hydrogenation;
参考文献
I.G.Farbenind.
Patent: DE526087 , 1928 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 464
Full Text Show Details
Winthrop Chem.Co.
Patent: US1913520 , 1928 ;
反应条件
silica gel in dimethyl sulfoxide
参考文献
Orsini, F.; Pelizzoni, F.; Forte, M.; Destro, R.; Gariboldi, P.
Tetrahedron, 1988 , vol. 44, # 2 p. 519 - 542
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol
参考文献
Sadet; Lipszyc; Chenu; et al.
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 277 - 288
