6,7-二氢噻吩并[3,2-c]吡啶-4(5h)-酮合成路线 （共 6 条）
反应条件
hydrogenchloride in ethanol
参考文献
Parcor
Patent: US4193997 A1, 1980 ;
反应条件
in acetic acid
Reflux;
参考文献
Milen, Matyas; Abranyi-Balogh, Peter; Dancso, Andras; Drahos, Laszlo; Keglevich, Gyoergy
Heteroatom Chemistry, 2013 , vol. 24, # 2 p. 124 - 130
反应条件
1: caesium carbonate / acetonitrile; dichloromethane / 24 h / 26 °C
2: 2-amino-2-methylpropionic acid / acetic acid / 6 h / |Reflux
View Scheme
参考文献
Milen, Matyas; Abranyi-Balogh, Peter; Dancso, Andras; Drahos, Laszlo; Keglevich, Gyoergy
Heteroatom Chemistry, 2013 , vol. 24, # 2 p. 124 - 130
反应条件
2-amino-2-methylpropionic acid in acetic acid
6 h; Reflux;
参考文献
Milen, Matyas; Abranyi-Balogh, Peter; Dancso, Andras; Drahos, Laszlo; Keglevich, Gyoergy
Heteroatom Chemistry, 2013 , vol. 24, # 2 p. 124 - 130
反应条件
1: sodium carbonate / chloroform / 0 - 20 °C
2: phosphorus pentoxide; trichlorophosphate / 4 h / 110 °C
View Scheme
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
反应条件
1: caesium carbonate / acetonitrile; dichloromethane / 24 h / 26 °C
2: acetic acid / |Reflux
View Scheme
参考文献
Milen, Matyas; Abranyi-Balogh, Peter; Dancso, Andras; Drahos, Laszlo; Keglevich, Gyoergy
Heteroatom Chemistry, 2013 , vol. 24, # 2 p. 124 - 130
