1-[三(1-甲基乙基)甲硅烷基]-1H-吡咯并[2,3-b]吡啶-5-醇合成路线 （共 7 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 2 h;
参考文献
L'Heureux, Alexandre; Thibault, Carl; Ruel, Rejean
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2317 - 2319
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C; 0.0333333 h;
2: With boric acid trimethyl ester in tetrahydrofuran
T=-78 - 20°C; 1 h;
参考文献
ABBOTT LABORATORIES
Patent: US2010/184766 A1, 2010 ;
Location in patent: Page/Page column 56 ;
反应条件
acetic acid; zinc in ethyl acetate
T=20°C; 18 h;
参考文献
L'Heureux, Alexandre; Thibault, Carl; Ruel, Rejean
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2317 - 2319
反应条件
1.1: sodium hydride / tetrahydrofuran; hexane / 0.25 h / 0 °C
1.2: 93.5 percent / tetrahydrofuran; hexane / 18 h / 80 °C
2.1: sec-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C
2.2: 65 percent / (R)-camphorsulfonyl oxaziridine / tetrahydrofuran; cyclohexane / 0.42 h / -78 °C
3.1: 49 percent / zinc; acetic acid / ethyl acetate / 18 h / 20 °C
View Scheme
参考文献
L'Heureux, Alexandre; Thibault, Carl; Ruel, Rejean
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2317 - 2319
反应条件
1.1: sodium hydride / tetrahydrofuran; hexane / 0.25 h / 0 °C
1.2: 93.5 percent / tetrahydrofuran; hexane / 18 h / 80 °C
2.1: sec-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C
2.2: 65 percent / (R)-camphorsulfonyl oxaziridine / tetrahydrofuran; cyclohexane / 0.42 h / -78 °C
3.1: 49 percent / zinc; acetic acid / ethyl acetate / 18 h / 20 °C
View Scheme
参考文献
L'Heureux, Alexandre; Thibault, Carl; Ruel, Rejean
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2317 - 2319
反应条件
1.1: sec-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C
1.2: 65 percent / (R)-camphorsulfonyl oxaziridine / tetrahydrofuran; cyclohexane / 0.42 h / -78 °C
2.1: 49 percent / zinc; acetic acid / ethyl acetate / 18 h / 20 °C
View Scheme
参考文献
L'Heureux, Alexandre; Thibault, Carl; Ruel, Rejean
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2317 - 2319
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h
1.2: 24 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.03 h / -78 °C
2.2: 1 h / -78 - 20 °C
2.3: 1 h / 0 °C
View Scheme
参考文献
ABBOTT LABORATORIES; TAO, Zhi-Fu; WANG, Xilu; SOUERS, Andrew J.; CATRON, Nathaniel D.; SULLIVAN, Gerard
Patent: WO2011/150016 A1, 2011 ;
