hydrogenchloride; water in 1,4-dioxane

1: With boron tribromide in dichloromethane T=-78 - -40°C; 0.666667 h; 2: With hydrogenchloride in water 1 h; Heating;

1.1: 76 mg / ruthenium(III) chloride hydrate; NaIO4 / CCl4; acetonitrile; H2O / 6 h 2.1: BBr3 / CH2Cl2 / 0.67 h / -78 - -40 °C 2.2: 50 percent / 37 percent hydrogen chloride / H2O / 1 h / Heating View Scheme

1.1: 69 percent / oxalyl chloride; dimethyl sulfoxide / CH2Cl2 / 0.33 h / -78 °C 2.1: 76 mg / ruthenium(III) chloride hydrate; NaIO4 / CCl4; acetonitrile; H2O / 6 h 3.1: BBr3 / CH2Cl2 / 0.67 h / -78 - -40 °C 3.2: 50 percent / 37 percent hydrogen chloride / H2O / 1 h / Heating View Scheme

1.1: 162 mg / LAH; aluminum chloride / tetrahydrofuran / 0 deg C, 30 min; reflux, 2 h 2.1: 69 percent / oxalyl chloride; dimethyl sulfoxide / CH2Cl2 / 0.33 h / -78 °C 3.1: 76 mg / ruthenium(III) chloride hydrate; NaIO4 / CCl4; acetonitrile; H2O / 6 h 4.1: BBr3 / CH2Cl2 / 0.67 h / -78 - -40 °C 4.2: 50 percent / 37 percent hydrogen chloride / H2O / 1 h / Heating View Scheme

potassium chloride T=37°C; other esters of isoguvacine; also in human serum solution and extract of rat brain; pH 7.35; rate of hydrolysis;

triethylamine in 1,4-dioxane; water 24 h; Ambient temperature;

hydrogenchloride Ambient temperature;