2-溴-2′-硝基苯乙酮合成路线 （共 32 条）
反应条件
1.1: K2CO3 / dimethylformamide / 0.5 h / 20 °C 1.2: 41 percent / dimethylformamide / 20 °C 2.1: 84 percent / NaH / dimethylformamide / 2 h / 20 °C 3.1: 33 percent / POCl3 / 3 h / Heating 4.1: 63 percent / HCl; H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr View Scheme
参考文献
Radl; Konvicka; Vachal
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 4 p. 855 - 862
参考文献
Gevekoht
Justus Liebigs Annalen der Chemie, 1883 , vol. 221, p. 335
参考文献
Navas 3rd., Frank; Bishop, Michael J; Garrison, Deanna T; Hodson, Stephen J; Speake, Jason D; Bigham, Eric C; Drewry, David H; Saussy, David L; Liacos, James H; Irving, Paul E; Gobel, M Jeffrey
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 4 p. 575 - 579
反应条件
1: H2 / platinum oxide / ethanol View Scheme
参考文献
Navas 3rd., Frank; Bishop, Michael J; Garrison, Deanna T; Hodson, Stephen J; Speake, Jason D; Bigham, Eric C; Drewry, David H; Saussy, David L; Liacos, James H; Irving, Paul E; Gobel, M Jeffrey
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 4 p. 575 - 579
反应条件
sodium hydroxide; sodium tetrahydroborate in tetrahydrofuran; ethanol; water 1.) 5 deg C 2.) 2 h Room temperature;
参考文献
Wierenga, Wendell; Harrison, Allen W.; Evans, Bruce R.; Chidester, Connie G.
Journal of Organic Chemistry, 1984 , vol. 49, # 3 p. 438 - 442
反应条件
according to the procedure of Almirante et al.;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 9 p. 2293 - 2297
反应条件
hydrogenchloride; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in sodium hydroxide; ethanol; dichloromethane
参考文献
Beecham Group p.l.c.
Patent: US4812470 A1, 1989 ;
反应条件
1.1: K2CO3 / dimethylformamide / 0.5 h / 20 °C
1.2: 40 percent / dimethylformamide / 2 h / 20 °C
2.1: NaH / tetrahydrofuran / 1 h / 20 °C
2.2: 90 percent / aq. NaOH / ethanol / 0.5 h / Heating
3.1: 70 percent / PCl5 / 3 h / Heating
4.1: 80 percent / HCl; H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr
View Scheme
参考文献
Radl; Konvicka; Vachal
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 4 p. 855 - 862
反应条件
1.1: EtONa / ethanol / 1 h / 0 °C
1.2: 92 percent / ethanol / 72 h / 20 °C
2.1: 80 percent / AcOH; NH3 / Heating
3.1: 97 percent / H2 / Pd/C / ethanol / 20 °C
View Scheme
参考文献
Testa, Maria Luisa; Lamartina, Liliana; Mingoia, Francesco
Tetrahedron, 2004 , vol. 60, # 28 p. 5873 - 5880
反应条件
2: NH3 / acetic acid / 3 h / Heating
3: 7 percent / nitric acid-acetic anhydride / nitromethane / -15 °C
4: 55 percent / iron powder, acetic acid / 13 h / 70 °C
View Scheme
参考文献
Aiello, Enrico; Dattolo, Gaetano; Cirrincione, Girolamo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1 - 3
