3-(2-脱氧-beta-D-赤式-呋喃戊糖基)-3H-咪唑并[2,1-I]嘌呤合成路线 （共 10 条）
反应条件
in water T=30°C; 12 h;
参考文献
Chirakul; Litzer; Sigurdsson
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1903 - 1913
反应条件
1: NH3 / methanol / Heating 2: aq. buffer (pH=4.5) View Scheme
参考文献
Journal of the American Chemical Society, , vol. 117, # 43 p. 10781 - 10782
反应条件
dipotassium hydrogenphosphate T=20°C; Condensation; cyclization; pH=7.4; 0.5 h;
参考文献
Journal of the American Chemical Society, , vol. 121, # 39 p. 9231 - 9232
反应条件
2,4-dinitro-phenol; ferrous iron; nicotinamide adenine dinucleotide; E. coli nitroreductase in phosphate buffer T=37°C; pH=7.0; 1 h;
参考文献
Environmental Toxicology, , vol. 22, # 2 p. 222 - 227
反应条件
1: aq. NH3 / 5.5 h / 55 °C 2: 92 percent / H2O / 12 h / 30 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 12 p. 1903 - 1913
反应条件
trans-N-deoxyribosylase from Lactobacillus helveticus in water T=37°C; trans-deoxyribosylation; 15 h; Enzymatic reactionproduct analyzed by HPLC; Product distribution;
参考文献
Mueller, Michael; Hutchinson, Linda K.; Peter Guengerich
Chemical Research in Toxicology, 1996 , vol. 9, # 7 p. 1140 - 1144
反应条件
3-(n-morpholino)-propane sulfonic acid; sodium chloride in ethanol T=37°C; pH=7.4; 48 h; Product distribution;
参考文献
Chemical Research in Toxicology, , vol. 15, # 3 p. 300 - 304
反应条件
1: 73 percent / aq. NaOH / 20 °C 2: 53 percent / aq. AcOH; NaNO2 / 1 h 3: 38 percent / NBS; aq. NaOAc buffer / 20 °C / pH 4.0 - 4.5 View Scheme
参考文献
Sugiyama, Tamizi; Schweinberger, Enno; Kazimierczuk, Zygmunt; Ramzaeva, Natalya; Rosemeyer, Helmut; Seela, Frank
Chemistry - A European Journal, 2000 , vol. 6, # 2 p. 369 - 378
反应条件
hydrogenchloride T=70°C; Hydrolysis; 1 h;
参考文献
Jones, Wendelyn R.; Dedon, Peter C.
Journal of the American Chemical Society, 1999 , vol. 121, # 39 p. 9231 - 9232
反应条件
1: 73 percent / aq. NaOH / 20 °C
2: 53 percent / aq. AcOH; NaNO2 / 1 h
3: 38 percent / NBS; aq. NaOAc buffer / 20 °C / pH 4.0 - 4.5
4: calf intestine adenosine deaminase; H2O / glycerol / 18 h / 20 °C
View Scheme
参考文献
Sugiyama, Tamizi; Schweinberger, Enno; Kazimierczuk, Zygmunt; Ramzaeva, Natalya; Rosemeyer, Helmut; Seela, Frank
Chemistry - A European Journal, 2000 , vol. 6, # 2 p. 369 - 378
