alpha-2-吡啶基-2,8-二(三氟甲基)-4-喹啉甲醇合成路线 （共 8 条）
反应条件
tetrabutyl ammonium fluoride; oxygen in acetonitrile Ambient temperature; Yield given;
参考文献
Adam
Tetrahedron, 1989 , vol. 45, # 5 p. 1409 - 1414
反应条件
1: O2, TBAF / acetonitrile / Ambient temperature 2: 80 percent / H2, HCl / PtO2 / methanol; ethanol / 5.5 h View Scheme
参考文献
Adam
Tetrahedron, 1989 , vol. 45, # 5 p. 1409 - 1414
反应条件
tetrabutyl ammonium fluoride in acetonitrile
0.166667 h; Ambient temperature;
参考文献
Adam
Tetrahedron, 1989 , vol. 45, # 5 p. 1409 - 1414
反应条件
1: 90 percent / NaH / toluene; dimethylformamide / 20 h / 110 °C
2: 0.5 g / BuLi / tetrahydrofuran; hexane / Ambient temperature
3: 45 percent / TBAF / acetonitrile / 0.17 h / Ambient temperature
View Scheme
参考文献
Adam
Tetrahedron, 1989 , vol. 45, # 5 p. 1409 - 1414
反应条件
1: 90 percent / NaH / toluene; dimethylformamide / 20 h / 110 °C
2: 0.5 g / BuLi / tetrahydrofuran; hexane / Ambient temperature
3: 45 percent / TBAF / acetonitrile / 0.17 h / Ambient temperature
View Scheme
参考文献
Adam
Tetrahedron, 1989 , vol. 45, # 5 p. 1409 - 1414
反应条件
1: 0.5 g / BuLi / tetrahydrofuran; hexane / Ambient temperature
2: 45 percent / TBAF / acetonitrile / 0.17 h / Ambient temperature
View Scheme
参考文献
Adam
Tetrahedron, 1989 , vol. 45, # 5 p. 1409 - 1414
反应条件
1: 95 percent / KOH / ethanol; methanol / 2 h / 60 °C
2: 90 percent / m-CPBA / CHCl3 / 12 h / Ambient temperature
3: 1) C6H5MgBr / 1) THF, 40 deg C, 1 h, 2) room temperature, 3 h
View Scheme
参考文献
Suresh Kumar; Nageshwar; Meshram
Synthetic Communications, 1996 , vol. 26, # 10 p. 1913 - 1919
反应条件
phenyl-magnesium bromide
1) THF, 40 deg C, 1 h, 2) room temperature, 3 h; Yield given. Multistep reaction;
参考文献
Suresh Kumar; Nageshwar; Meshram
Synthetic Communications, 1996 , vol. 26, # 10 p. 1913 - 1919
