3-氯-N,N-二甲基苯胺合成路线 （共 30 条）
反应条件
hydrogenchloride; 18-crown-6 ether; iodine; hexacarbonyl chromium 1.) diglyme, cyclohexane, reflux, 95 h, 2.) benzene, 70 deg C, 1.0 h, 3.) THF, R.T., 30 min; Yield given. Multistep reaction;
参考文献
Fukui; Endo; Oishi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 12 p. 3639 - 3648
反应条件
1: concentrated hydrochloric acid; formaldehyde; hydrochloride of 4-nitroso-dimethylaniline / man faellt mit Soda und kocht die erhaltene Verbindung in einem Gemisch von Alkohol und Eisessig mit Formaldehydloesung
2: concentrated sulfuric acid; HNO3+H2SO4 / <10
View Scheme
参考文献
Ullmann; Frey
Chemische Berichte, 1904 , vol. 37, p. 862
参考文献
Schmidt; Fischer
Chemische Berichte, 1920 , vol. 53, p. 1539
参考文献
Schmidt; Fischer
Chemische Berichte, 1920 , vol. 53, p. 1539
反应条件
pyridine; tert.-butylhydroperoxide; iron(II) chloride in acetonitrile
T=85°C; 2 h; Inert atmosphere; chemoselective reaction;
参考文献
Li, Yuanming; Ma, Lina; Jia, Fan; Li, Zhiping
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5638 - 5646
参考文献
Staedel
Chemische Berichte, 1886 , vol. 19, p. 1948
参考文献
Staedel
Chemische Berichte, 1886 , vol. 19, p. 1948
参考文献
v.Braun; Kruber
Chemische Berichte, 1913 , vol. 46, p. 3463
参考文献
v.Braun; Kruber
Chemische Berichte, 1913 , vol. 46, p. 3463
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; palladium dichloride; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in dimethyl sulfoxide
T=120°C; 24 h; Inert atmosphere;
参考文献
Li, Xiang; Yang, Fan; Wu, Yangjie
RSC Advances, 2014 , vol. 4, # 26 p. 13738 - 13741
