5-氨基-1-苄基-1H-咪唑-4-羧酸乙酯合成路线 （共 15 条）
反应条件
1: ethyl (hydroxylimino)cyanoacetate With sodium dithionite; sodium hydrogencarbonate in water 2: orthoformic acid triethyl ester in acetonitrile 0.5 h; Reflux; 3: benzylamine in acetonitrile 0.5 h; Reflux;
参考文献
SCHERING CORPORATION; TULSHIAN, Deen; MATASI, Julius, J.; CZARNIECKI, Michael, F.; BRUMFIELD, Stephanie Nicole
Patent: WO2011/79000 A1, 2011 ;
Location in patent: Page/Page column 36; 37 ;
WO 2011/079000 A1
反应条件
1: orthoformic acid triethyl ester; 2-amino-2-cyanoacetic acid ethyl ester in acetonitrile 0.833333 h; Heating; 2: benzylamine in acetonitrile T=20°C; 16 h; Further stages.;
参考文献
Lin, Xiaoyu; Robins, Morris J.
Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 7 p. 1029 - 1041
反应条件
1.1: 68 percent / aq. NaHCO3; sodium dithionite / 0.5 h / 20 °C 2.1: acetonitrile / 0.83 h / Heating 2.2: 45 percent / acetonitrile / 16 h / 20 °C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 71, # 7 p. 1029 - 1041
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 173 - 175
反应条件
1: H2O2, Na2MoO4 2: NaOCl View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 173 - 175
反应条件
2: H2O2, Na2MoO4 3: NaOCl View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 173 - 175
反应条件
1: acetonitrile / 0.75 h / Reflux 2: acetonitrile View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 4 p. 412 - 415
参考文献
Tetrahedron Letters, , vol. 53, # 4 p. 412 - 415
反应条件
1.) acetonitrile, 35 min, reflux, 2.) 15 min, reflux; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2310 - 2315
反应条件
in pyridine T=55°C; 3 h;
参考文献
Mackenzie, Grahame; Wilson, Hilary A.; Shaw, Gordon; Ewing, David
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2541 - 2546
