4-(1-哌啶基甲基)苯甲酸甲酯合成路线 （共 12 条）
反应条件
caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; palladium diacetate in tetrahydrofuran; water T=80°C; Suzuki-Miyaura cross-coupling;
参考文献
Molander, Gary A.; Sandrock, Deidre L.
Organic Letters, 2007 , vol. 9, # 8 p. 1597 - 1600
反应条件
1: With titanium(IV) isopropylate in methanol T=20°C; 3 h; 2: With sodium cyanoborohydride in methanol
参考文献
Miko, Tibor; Ligneau, Xavier; Pertz, Heinz H.; Ganellin, C. Robin; Arrang, Jean-Michel; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1523 - 1530
反应条件
methyl-diethoxy-silane; zinc diacetate in tetrahydrofuran T=65°C; Inert atmosphere; chemoselective reaction;
参考文献
Das, Shoubhik; Addis, Daniele; Junge, Kathrin; Beller, Matthias
Chemistry - A European Journal, 2011 , vol. 17, # 43 p. 12186 - 12192
反应条件
copper(II) bis(trifluoromethanesulfonate) T=20°C; 16 h;
参考文献
Broehmer, Manuel C.; Mundinger, Stephan; Braese, Stefan; Bannwarth, Willi
Angewandte Chemie - International Edition, 2011 , vol. 50, # 27 p. 6175 - 6177
反应条件
in dichloromethane 2 h; Reflux;
参考文献
Sheng, Rong; Xu, Yu; Hu, Chunqi; Zhang, Jing; Lin, Xiao; Li, Jingya; Yang, Bo; He, Qiaojun; Hu, Yongzhou
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 7 - 17
反应条件
1: piperidine; C26H28N5O3Pol With sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane T=20°C; 12 h; solid phase reaction; 2: methanol With copper(II) bis(trifluoromethanesulfonate) T=20°C; 15 h; solid phase reaction;
参考文献
Kramer, Rolf A.; Broehmer, Manuel C.; Forkel, Nina V.; Bannwarth
European Journal of Organic Chemistry, 2009 , # 25 p. 4273 - 4283
反应条件
copper(II) bis(trifluoromethanesulfonate) T=20°C; 12 h; solid phase reaction;
参考文献
European Journal of Organic Chemistry, , # 26 p. 4412 - 4415
反应条件
1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C 2: sodium tris(acetoxy)borohydride / 20 °C / Inert atmosphere 3: copper(II) bis(trifluoromethanesulfonate) / 16 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 27 p. 6175 - 6177
反应条件
1: sodium tris(acetoxy)borohydride / 20 °C / Inert atmosphere 2: copper(II) bis(trifluoromethanesulfonate) / 16 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 27 p. 6175 - 6177
反应条件
ammonia T=25°C; Kinetics;
参考文献
Journal of Organic Chemistry, , vol. 76, # 5 p. 1425 - 1435
