苯并[1,3]二氧代-5-乙酰氯合成路线 （共 14 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in toluene T=20°C; 1 h; Inert atmosphere;
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Sattler, Johann H.; Lienhart, Wolf-Dieter; Durchschein, Katharina; Winkler, Andreas; Gruber, Karl; MacHeroux, Peter; Kroutil, Wolfgang
Angewandte Chemie - International Edition, 2011 , vol. 50, # 5 p. 1068 - 1071
反应条件
1: 97 percent / 20percent aq. KOH / methanol / 3 h / Heating 2: SOCl2 / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1794 - 1801
反应条件
1: 97 percent / conc. H2SO4 / 3 h / Heating 2: 55 percent / CsF / dimethylformamide / 3 h / Heating 3: 97 percent / 20percent aq. KOH / methanol / 3 h / Heating 4: SOCl2 / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1794 - 1801
反应条件
1: 55 percent / CsF / dimethylformamide / 3 h / Heating 2: 97 percent / 20percent aq. KOH / methanol / 3 h / Heating 3: SOCl2 / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 11 p. 1794 - 1801
反应条件
1: 76 percent / NaOH / 3 h / 80 °C 2: 90 percent / copper(II) chloride dihydrate, HCl / 23 h / Heating 3: 87 percent / 1N NaOH / tetrahydrofuran / 1.5 h / Ambient temperature 4: oxalyl chloride / CH2Cl2 / 15 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 10 p. 1972 - 1979
反应条件
1: 87 percent / 1N NaOH / tetrahydrofuran / 1.5 h / Ambient temperature 2: oxalyl chloride / CH2Cl2 / 15 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 10 p. 1972 - 1979
反应条件
1: 90 percent / copper(II) chloride dihydrate, HCl / 23 h / Heating 2: 87 percent / 1N NaOH / tetrahydrofuran / 1.5 h / Ambient temperature 3: oxalyl chloride / CH2Cl2 / 15 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 10 p. 1972 - 1979
反应条件
1.1: sodium hydroxide / dichloromethane; water / 16 h / 0 - 20 °C 2.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere 2.2: 0.5 h / 20 °C View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
反应条件
in dichloromethane; water
T=20°C;
参考文献
Brown; Bataille; Bruton; Hinks; Swain
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6719 - 6728
反应条件
1: 59 percent / AlCl3 / nitromethane / 1.) 0 deg C, 3 h, 2.) RT, 20 h
2: 28 percent / 1.5 h / 90 °C
View Scheme
参考文献
Schuda, Paul Francis; Price, William A.
Journal of Organic Chemistry, 1987 , vol. 52, # 10 p. 1972 - 1979
