7-甲氧基-1-萘基乙酸乙酯合成路线 （共 11 条）
反应条件
sulfur T=215 - 225°C;
参考文献
CADILA PHARMACEUTICALS LTD; KHAMAR, Bakulesh Mafatlal; BHUVA, Chirag Vithalbhai; MUGALE, Balaji Ram; KANANI, Ashok Ratilal; KAGATHARA, Nirav Keshavlal; BAPAT, Uday Rajaram; MODI, Indravadan Ambalal
Patent: WO2012/70025 A1, 2012 ;
Location in patent: Page/Page column 9-10 ;
反应条件
sulfur in ethyl acetate T=215°C; 10 h;
参考文献
EP2474522 A1, ;
Page/Page column 7 ;
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane T=15 - 20°C;
参考文献
Tang, Jia-Deng; Cen, Jun-Da
Organic Preparations and Procedures International, 2009 , vol. 41, # 2 p. 164 - 168
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane T=15 - 20°C;
参考文献
Tang, Jia-Deng; Cen, Jun-Da
Organic Preparations and Procedures International, 2009 , vol. 41, # 2 p. 164 - 168
反应条件
1: 1.) N-isopropylcyclohexylamine, n-butyllithium / 1.) THF, hexane, -75 deg C, 15 min, 2.) THF, hexane, -78 deg C, 1.5 h 2: 81 percent / 10percent Pd/C, 1,1-diphenylethylene, 1-methylnaphthalene / 3 h / 250 - 260 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 26 p. 5550 - 5556
反应条件
1: 83 percent / polyphosphoric acid / 0.12 h / 90 - 100 °C 2: 1.) N-isopropylcyclohexylamine, n-butyllithium / 1.) THF, hexane, -75 deg C, 15 min, 2.) THF, hexane, -78 deg C, 1.5 h 3: 81 percent / 10percent Pd/C, 1,1-diphenylethylene, 1-methylnaphthalene / 3 h / 250 - 260 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 26 p. 5550 - 5556
反应条件
1: With sodium hydroxide; water in methanol T=40°C; 2 h; 2: With hydrogenchloride in water pH=2;
参考文献
US2008/280991 A1, ;
Page/Page column 35 ;
US 20080280991 A1
反应条件
1.1: sodium hydroxide; water / ethanol / 3 h / 20 °C 2.1: thionyl chloride / dichloromethane / 2 h / Reflux 3.1: ammonia / ethyl acetate; water / Cooling with ice 4.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice 5.1: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave 6.1: pyridine / 40 °C 6.2: 20 °C / Cooling with ice View Scheme
参考文献
Procos S.p.A.; Barozza, Alessandro; Veronese, Martino; Roletto, Jacopo; Paissoni, Paolo
Patent: EP2703383 A1, 2014 ;
反应条件
1: sodium hydroxide; water / ethanol / 3 h / 20 °C 2: thionyl chloride / dichloromethane / 2 h / Reflux 3: ammonia / ethyl acetate; water / Cooling with ice 4: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice 5: hydrogen; ammonia / ethanol; water / 12 h / 60 °C / 228015 Torr / Autoclave View Scheme
参考文献
Procos S.p.A.; Barozza, Alessandro; Veronese, Martino; Roletto, Jacopo; Paissoni, Paolo
Patent: EP2703383 A1, 2014 ;
反应条件
1: sodium hydroxide; water / ethanol / 3 h / 20 °C 2: thionyl chloride / dichloromethane / 2 h / Reflux 3: ammonia / ethyl acetate; water / Cooling with ice View Scheme
参考文献
Tianjin Taipu Pharmaceutical Science and Technology Development Co., Ltd.
Patent: EP2474522 A1, 2012 ;
