3-甲氧基-N-苯基苯甲酰胺合成路线 （共 27 条）
反应条件
1: 74 percent / Lawesson's reagent / chlorobenzene / 3 h / Heating 2: 80 percent / aq. NaOH, potassium ferricyanide / 3 h / Heating; var. thiobenzanilides View Scheme
参考文献
Inamoto, Kiyofumi; Nozawa, Kanako; Kondo, Yoshinori
Synlett, 2012 , vol. 23, # 11 p. 1678 - 1682
反应条件
1: 51 percent / sec-BuLi; tetramethylenediamine / cyclohexane; tetrahydrofuran / 20 °C
2: LiAlH4 / tetrahydrofuran
3: KMnO4 / acetone; aq. NaHCO3
4: 44 percent / H3PO4 / toluene; xylene / Heating
View Scheme
参考文献
Foye, William O.; Wang, Xiping; Hongfu, Wang
Medicinal Chemistry Research, 1997 , vol. 7, # 3 p. 180 - 191
反应条件
1: 1.) n-BuLi / 1.) THF, RT, 2 h, 2.) THF, RT, 1 h
2: SOCl2 / 4 h / Heating
3: NaHCO3 / CH2Cl2
View Scheme
参考文献
Lambert; Hilbert; Christiaens
Synthetic Communications, 1991 , vol. 21, # 1 p. 85 - 98
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; cyclohexane
T=20°C; cyclocondensation; 1 h;
参考文献
Foye, William O.; Wang, Xiping; Hongfu, Wang
Medicinal Chemistry Research, 1997 , vol. 7, # 3 p. 180 - 191
反应条件
1: 3-Methoxy-N-phenylbenzamide With n-butyllithium in tetrahydrofuran
T=-78 - 20°C; Metallation; 1.5 h;
2: ortho-anisaldehyde in tetrahydrofuran
T=-78 - 20°C; Cycloaddition; 2 h;
参考文献
Epsztajn; Bieniek; Kowalska; Kulikiewicz
Synthesis, 2000 , # 11 p. 1603 - 1607
反应条件
1.1: n-(C4H9)Li / tetrahydrofuran; hexane / -78 - 20 °C
1.2: tetrahydrofuran; hexane / 1 h / -78 °C
2.1: HCl / H2O; tetrahydrofuran; hexane / 20 °C
View Scheme
参考文献
Bieniek, Adam; Epsztajn, Jan; Kulikiewicz, Krystyna K.
Synthetic Communications, 2003 , vol. 33, # 4 p. 667 - 677
反应条件
1: 75 percent / BuLi / tetrahydrofuran / 1.) -78 deg C, 0.5 h; 0 deg C, 0.1 h, 2.) -78 deg C, 1 h; r.t., 1 h
2: Zn-Cu, LiOH / H2O / 1 h / Heating
3: HCl / H2O
View Scheme
参考文献
Epsztajn, Jan; Jozwiak, Andrzej; Szczesniak, Aleksandra K.
Tetrahedron, 1993 , vol. 49, # 4 p. 929 - 938
