2-丁基-4-羟甲基咪唑合成路线 （共 16 条）
反应条件
ammonia T=60°C; Cyclization; high pressure;
参考文献
Shilcrat, Susan C.; Mokhallalati, Mohamed K.; Fortunak, Joseph M. D.; Pridgen, Lendon N.
Journal of Organic Chemistry, 1997 , vol. 62, # 24 p. 8449 - 8454
反应条件
diisobutylaluminium hydride in toluene
参考文献
Boschelli, Diane H.; Connor, David T.
Heterocycles, 1993 , vol. 35, # 1 p. 121 - 124
反应条件
ammonia P=2327.2 Torr; a) 25 deg C, 0.75 h, b) 70 deg C, 0.45 h;
参考文献
Shi; Frey; Tschaen; Verhoeven
Synthetic Communications, 1993 , vol. 23, # 18 p. 2623 - 2630
反应条件
1: 72 percent / hydrogen chloride / 18 h / 0 - 15 °C 2: 75 percent / NH3 / 60 °C / high pressure View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454
反应条件
in water Alkylation;
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454
反应条件
N-chloro-succinimide
参考文献
Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha
Patent: US5395943 A1, 1995 ;
反应条件
N-chloro-succinimide in tetrahydrofuran; diethyl ether
参考文献
SmithKline Beecham Corporation
Patent: US5447949 A1, 1995 ;
US 5447949 A
反应条件
N-chloro-succinimide in 1,4-dioxane; water; ethyl acetate
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4340598 A1, 1982 ;
反应条件
N-chloro-succinimide in tetrahydrofuran
参考文献
Synthetic Communications, , vol. 23, # 18 p. 2623 - 2630
反应条件
in tetrahydrofuran; 2-methoxy-ethanol; water
参考文献
SmithKline Beecham Corporation
Patent: US5728842 A1, 1998 ;
US 5728842 A
