N-(2-溴噻吩-5-基)-乙酰胺合成路线 （共 7 条）
反应条件
sodium hydroxide; p-toluenesulfonyl chloride in acetone T=0°C;
参考文献
Conde, Santiago; Corral, Carlos; Lissavetzky, Jaime
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 301 - 304
反应条件
1: With iron; acetic acid T=100°C; 0.5 h; 2: With water; sodium hydroxide in tetrahydrofuran; methanol T=20°C; 0.5 h;
参考文献
WO2014/59333 A1, ;
Paragraph 00472 ;
反应条件
phosphorus pentachloride in diethyl ether 1.) 0 deg C, 2 h, 2.) ambient temperature, 20 h; Title compound not separated from byproducts;
参考文献
Synthesis, , # 2 p. 133 - 135
反应条件
1: With hydroxylamine in ethanol Heating; 2: With ytterbium trifluoromethanesulfonate in acetonitrile Beckmann rearrangement; 24 h; Heating;
参考文献
Nurkkala, Lasse J.; Steen, Robert O.; Dunne, Simon J.
Synthesis, 2006 , # 8 p. 1295 - 1300
反应条件
acetic acid T=120°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 21 p. 5567 - 5571
反应条件
trichlorophosphate in various solvent(s) 12 h; Heating;
参考文献
Meth-Cohn, Otto; Narine, Brahma; Tarnowski, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1531 - 1536
反应条件
1.1: 31 percent / POCl3 / 1,1,2,2-tetrachloro-ethane / 125 °C
2.1: n-BuLi / diethyl ether / -35 °C
2.2: 85 percent / H2O / diethyl ether
View Scheme
参考文献
Nurkkala, Lasse J.; Steen, Robert O.; Dunne, Simon J.
Synthesis, 2006 , # 8 p. 1295 - 1300
