7-氯-1-乙基-6-氟-1,4-二氢-4-羰基喹啉-3-羧酸合成路线 （共 26 条）
反应条件
1: 95 percent / BF3*Et2O / diethyl ether; CH2Cl2 / Heating 2: 98 percent / triethylamine / dimethylsulfoxide / 3 h / 60 °C 3: 98 percent / aq. NaOH / Heating View Scheme
参考文献
Heravi, Majid M.; Jaddi, Zeinab S.; Oskooie, Hossein A.; Khaleghi, Shahnaz; Ghassemzadeh, Mitra
Journal of Chemical Research, 2005 , # 9 p. 578 - 579
参考文献
Journal of Medicinal Chemistry, , vol. 23, # 12 p. 1358 - 1363
反应条件
sodium tetrahydroborate in methanol 1 h; Heating;
参考文献
Radl, Stanislav; Janichova, Magda
Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 1 p. 188 - 193
反应条件
1: 66 percent / 5 h / 130 - 140 °C
2: 89 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 66 percent / 5 h / 130 - 140 °C
2: 97 percent / Et3N / 90 - 100 °C
View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 0.333333 h; microwave irradiation;
2: With hydrogenchloride in water
pH=7;
参考文献
Heravi, Majid M.; Oskooie, Hossein A.; Motamedi, Radineh; Ghassemzadeh, Mitra
Heterocyclic Communications, 2005 , vol. 11, # 5 p. 423 - 426
