7-氯-1-乙基-6-氟-1,4-二氢-4-羰基喹啉-3-羧酸合成路线 （共 26 条）
反应条件
1: With water; sodium hydroxide in ethanol T=90°C; 1.5 h; 2: With hydrogenchloride in ethanol; water pH=2;
参考文献
Niedermeier, Sabine; Singethan, Katrin; Rohrer, Sebastian G.; Matz, Magnus; Kossner, Markus; Diederich, Sandra; Maisner, Andrea; Schmitz, Jens; Hiltensperger, Georg; Baumann, Knut; Holzgrabe, Ulrike; Schneider-Schaulies, Jurgen
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4257 - 4265
反应条件
aluminium trichloride in chlorobenzene T=80°C; 0.0833333 h;
参考文献
Jordis, Ulrich; Sauter, Fritz; Burkart, Michael; Henning, Hans-Georg; Gelbin, Anke
Journal fuer Praktische Chemie (Leipzig), 1991 , vol. 333, # 2 p. 267 - 279
反应条件
1: K2CO3 2: aq. NaOH View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 38, # 11-12 p. 1001 - 1004
反应条件
trichlorophosphate T=100°C;
参考文献
Jackson, Andrew; Meth-Cohn, Otto
Journal of the Chemical Society, Chemical Communications, 1995 , # 13 p. 1319 - 1320
反应条件
1: 100 percent / 2 h / 120 - 130 °C 2: diphenyl ether / 1 h / Heating 3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 4: 90 percent / 2N NaOH / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 23, # 12 p. 1358 - 1363
反应条件
1: diphenyl ether / 1 h / Heating 2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 3: 90 percent / 2N NaOH / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 23, # 12 p. 1358 - 1363
反应条件
1: 54 percent / pyridine / dioxane / 1.) 2 h, room temperature, 2.) 1 h, 70 - 80 deg C. 2: 74 percent / potassium t-butylate / dioxane / 1.) 30 min, room temperature, 2.) 2 h, reflux 3: 91 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
1: 54 percent / pyridine / dioxane / 1.) 2 h, room temperature, 2.) 1 h, 70 - 80 deg C. 2: 74 percent / potassium t-butylate / dioxane / 1.) 30 min, room temperature, 2.) 2 h, reflux 3: 91 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
1: 74 percent / potassium t-butylate / dioxane / 1.) 30 min, room temperature, 2.) 2 h, reflux 2: 91 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile
参考文献
Zhi, Chengxin; Wright, George E.
Patent: US2003/181719 A1, 2003 ;
US 20030181719 A1
