N1,N5-双-Boc-亚精胺合成路线 （共 19 条）
反应条件
sodium hydroxide; hydrogen; nickel in ethanol T=30°C; P=2250.23 Torr; 18 h;
参考文献
WO2005/116050 A1, ;
Page/Page column 31 ;
反应条件
1: 76 percent / CH2Cl2 / 6.5 h / 20 °C 2: 90 percent / methanol / 12 h / 0 - 20 °C 3: 92 percent / CH2Cl2 / 4.5 h / 20 °C 4: 65 percent / LiAlH4 / diethyl ether / 3 h / 0 - 20 °C View Scheme
参考文献
Biological and Pharmaceutical Bulletin, , vol. 30, # 6 p. 1117 - 1122
反应条件
1: 90 percent / methanol / 12 h / 0 - 20 °C 2: 92 percent / CH2Cl2 / 4.5 h / 20 °C 3: 65 percent / LiAlH4 / diethyl ether / 3 h / 0 - 20 °C View Scheme
参考文献
Biological and Pharmaceutical Bulletin, , vol. 30, # 6 p. 1117 - 1122
反应条件
1: 92 percent / CH2Cl2 / 4.5 h / 20 °C 2: 65 percent / LiAlH4 / diethyl ether / 3 h / 0 - 20 °C View Scheme
参考文献
Biological and Pharmaceutical Bulletin, , vol. 30, # 6 p. 1117 - 1122
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 43, # 10 p. 990 - 994
反应条件
1: 84 percent / Et3N / dioxane; H2O / 72 h / 23 °C 2: 82 percent / hydrogen, NaOH / Raney Ni / ethanol; H2O / 2625.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 77, # 5 p. 1229 - 1235
反应条件
1: 84 percent / Et3N / dioxane; H2O / 72 h / 23 °C 2: 82 percent / hydrogen, NaOH / Raney Ni / ethanol; H2O / 2625.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 77, # 5 p. 1229 - 1235
反应条件
hydrazine hydrate in ethanol T=80°C; 1 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2759 - 2763
反应条件
1: 87 percent / CH2Cl2 / Ambient temperature 2: 98 percent / H2 / Pd View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 43, # 10 p. 990 - 994
反应条件
1: Et3N, / tetrahydrofuran / 1 h / 0 - 5 °C 2: Et3N / acetonitrile; CH2Cl2 / 4 h / Ambient temperature 3: 1.) borane-methyl sulphide, 2.) MeOH-HCl, 3.) Na2CO3 4: 95 percent / NaH, NaI / toluene; dimethylformamide / 16 h / 60 °C 5: 748 mg / Nh2NH2*H2O / ethanol / 1 h / 80 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2759 - 2763
