4-氯-2-硝基苯基硫氰酸酯合成路线 （共 11 条）
参考文献
Pilgram,K.; Korte,F.
Tetrahedron, 1964 , vol. 20, p. 177 - 187
反应条件
hydrogenchloride; tin in water T=20 - 100°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 24 p. 8206 - 8220
反应条件
2: AcOOH / acetic acid View Scheme
参考文献
Pilgram,K.; Korte,F.
Tetrahedron, 1964 , vol. 20, p. 177 - 187
反应条件
1: 1-amino-2-nitro-4-chlorobenzene With sulfuric acid; sodium nitrite in water
T=0°C; 2 h;
2: copper(I) isothiocyanate; potassium thioacyanate in water
T=0 - 70°C; Sandmeyer reaction;
参考文献
Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 24 p. 8206 - 8220
反应条件
sulfuric acid; nitric acid
T=5 - 10°C;
参考文献
Challenger; Collins
Journal of the Chemical Society, 1924 , vol. 125, p. 1379
反应条件
1: potassium thiocyanate; water
2: HNO3+H2SO4 / 5 - 10 °C
View Scheme
参考文献
Challenger; Collins
Journal of the Chemical Society, 1924 , vol. 125, p. 1379
反应条件
1: chlorine; chloroform
2: glacial acetic acid
View Scheme
参考文献
Zincke
Justus Liebigs Annalen der Chemie, 1918 , vol. 416, p. 103
参考文献
Zincke
Justus Liebigs Annalen der Chemie, 1918 , vol. 416, p. 103
反应条件
(i) NaNO2, aq. HCl, HCO2H, (ii) CuCl; Multistep reaction;
参考文献
Martani,A. et al.
Bollettino Chimico Farmaceutico, 1962 , vol. 101, p. 829 - 840
反应条件
(i) aq. H2SO4, NaNO2, (ii) /BRN= 3594799/, CuSCN; Multistep reaction;
参考文献
Jackson,F.H.; Peters,A.T.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 268 - 272
