3-氨基-5-羟基苯甲酸甲酯合成路线 （共 5 条）
反应条件
1: 3,5-di(hydroxy)benzoic acid With ammonium hydroxide; ammonium chloride T=180°C; 40 h; 2: methanol With sulfuric acid in sulfuric acid 36 h; Reflux;
参考文献
Nawrat, Christopher C.; Palmer, Leoni I.; Blake, Alexander J.; Moody, Christopher J.
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5587 - 5603
参考文献
WO2004/60376 A1, ;
Page/Page column 245-246 ;
反应条件
ammonium hydroxide; sulfuric acid; ammonium chloride 1.) 180 deg C, 40 h, under pressure, 2.) reflux, 36 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 39, # 24 p. 4189 - 4192
反应条件
sodium hydrogencarbonate in tetrahydrofuran T=20°C; 36 h;
参考文献
Frenzel, Thomas; Bruenjes, Marco; Quitschalle, Monika; Kirschning, Andreas
Organic Letters, 2006 , vol. 8, # 1 p. 135 - 138
反应条件
1: With hydrogenchloride; sodium nitrite in 1,4-dioxane; water
T=0°C; 0.25 h;
2: With potassium iodide in 1,4-dioxane; water
T=10°C; 0.166667 h;
参考文献
Iino, Tomoharu; Hashimoto, Noriaki; Sasaki, Kaori; Ohyama, Sumika; Yoshimoto, Riki; Hosaka, Hideka; Hasegawa, Takuro; Chiba, Masato; Nagata, Yasufumi; Eiki, Jun-ichi; Nishimura, Teruyuki
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 11 p. 3800 - 3809
