alpha-(二乙基氨基)苯乙酸乙酯合成路线 （共 11 条）
反应条件
1: in diethyl ether; toluene
T=30°C; 0.25 h; Inert atmosphere;
2: With water; ammonium chloride in diethyl ether; toluene
ConcentrationSolventTemperatureTime;
参考文献
Hata, Shingo; Maeda, Tatsuya; Shimizu, Makoto
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 11 p. 1203 - 1205
反应条件
1: in diethyl ether; toluene
T=30°C; 0.25 h; Inert atmosphere;
2: With water; ammonium chloride in diethyl ether; toluene
ConcentrationSolventTemperatureTime;
参考文献
Hata, Shingo; Maeda, Tatsuya; Shimizu, Makoto
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 11 p. 1203 - 1205
反应条件
Cu(homoscorpionate) in 1,2-dichloro-ethane
T=20°C;
参考文献
Morilla, M. Esther; Diaz-Requejo, M. Mar; Belderrain, Tomas R.; Nicasio, M. Carmen; Trofimenko, Swiatoslaw; Perez, Pedro J.
Chemical Communications, 2002 , # 24 p. 2998 - 2999
反应条件
1: in diethyl ether; toluene
T=20°C; 1 h; Inert atmosphere;
2: With water; ammonium chloride in diethyl ether; toluene
参考文献
Hata, Shingo; Maeda, Tatsuya; Shimizu, Makoto
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 11 p. 1203 - 1205
反应条件
1: in diethyl ether; toluene
T=30°C; 1 h; Inert atmosphere;
2: With water; ammonium chloride in diethyl ether; toluene
参考文献
Hata, Shingo; Maeda, Tatsuya; Shimizu, Makoto
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 11 p. 1203 - 1205
反应条件
1: in toluene
T=-78°C; 0.5 h; Inert atmosphere;
2: With water; ammonium chloride in toluene
参考文献
Hata, Shingo; Maeda, Tatsuya; Shimizu, Makoto
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 11 p. 1203 - 1205
反应条件
1: pyridine; hydroxylamine hydrochloride / 3 h / |Reflux; |Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 0 - 20 °C / |Inert atmosphere
3: toluene; diethyl ether / 0.25 h / 30 °C / |Inert atmosphere
View Scheme
参考文献
Hata, Shingo; Maeda, Tatsuya; Shimizu, Makoto
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 11 p. 1203 - 1205
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 0 - 20 °C / |Inert atmosphere
2: toluene; diethyl ether / 0.25 h / 30 °C / |Inert atmosphere
View Scheme
参考文献
Hata, Shingo; Maeda, Tatsuya; Shimizu, Makoto
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 11 p. 1203 - 1205
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 0 - 20 °C / |Inert atmosphere
2: toluene; diethyl ether / 1 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Hata, Shingo; Maeda, Tatsuya; Shimizu, Makoto
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 11 p. 1203 - 1205
反应条件
ZnCl2*Et2O
THF, 1.) 25 deg C, 45 min, 2.) room temp., 30 min; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Urogdi, Laszlo; Mayence, Annie
Synthesis, 1989 , # 4 p. 323 - 327
