4-氯-5-羟基-2-甲基-2H-吡嗪-3-酮合成路线 （共 3 条）
反应条件
1: With water; potassium hydroxide in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=125°C; 4 h;
2: With hydrogenchloride in water
参考文献
PIERRE FABRE MEDICAMENT; DUPONT-PASSELAIGUE, Elisabeth; MIALHE, Samuel; RIEU, Jean-Pierre; JUNQUERO, Didier; VALEILLE, Karine
Patent: WO2011/15629 A1, 2011 ;
Location in patent: Page/Page column 58 ;
WO 2011/015629 A1
反应条件
morpholine
T=100°C; 2 h;
参考文献
Nagashima, Hiromu; Oda, Hirohisa; Hayakawa, Takahisa; Kaji, Kenji
Heterocycles, 1987 , vol. 26, # 1 p. 1 - 4
反应条件
1: Et3N / CH2Cl2 / 0.5 h / -5 °C
2: 83 percent / Pd2Cl2(PPh3)2; CuI; n-Bu4NI / Et3N / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
R'kyek, Omar; Maes, Bert U.W; Jonckers, Tim H.M; Lemiere, Guy L.F; Dommisse, Roger A
Tetrahedron, 2001 , vol. 57, # 50 p. 10009 - 10016
