螺[3H-吲哚-3,3'-吡咯烷]-2(1H)-酮合成路线 （共 25 条）
反应条件
1: 1.) NaH
2: 1.) n-Bu3SnH, AIBN, 2.) Mg / 1.) benzene, 80 deg C, 1 h, 2.) MeOH, 24 h, room t.
3: TFA
View Scheme
参考文献
Cossy, Janine; Cases, Manuel; Gomez Pardo, Domingo
Tetrahedron Letters, 1998 , vol. 39, # 16 p. 2331 - 2332
反应条件
1: 1.) n-Bu3SnH, AIBN, 2.) Mg / 1.) benzene, 80 deg C, 1 h, 2.) MeOH, 24 h, room t.
2: TFA
View Scheme
参考文献
Cossy, Janine; Cases, Manuel; Gomez Pardo, Domingo
Tetrahedron Letters, 1998 , vol. 39, # 16 p. 2331 - 2332
反应条件
trifluoroacetic acid
参考文献
INCYTE CORPORATION
Patent: WO2006/55752 A2, 2006 ;
Location in patent: Page/Page column 24 ;
WO 2006/055752 A2
反应条件
potassium carbonate in acetonitrile
T=20°C;
参考文献
Goermen, Meral; Le Goff, Ronan; Lawson, Ata Martin; Daich, Adam; Comesse, Sebastien
Tetrahedron Letters, 2013 , vol. 54, # 17 p. 2174 - 2176
反应条件
sodium cyanoborohydride; acetic acid
Methylation;
参考文献
Somei; Noguchi; Yamagami; Kawada; Yamada
Heterocycles, 2000 , vol. 53, # 1 p. 7 - 10
