3,4-二氢-2H-苯并[b]噁嗪-5-酮合成路线 （共 21 条）
反应条件
hydrogenchloride; aluminium trichloride in diethyl ether; 1,2-dichloro-ethane
参考文献
Lloyd, David G.; Hughes, Rosario B.; Zisterer, Daniela M.; Williams, D. Clive; Fattorusso, Caterina; Catalanotti, Bruno; Campiani, Giuseppe; Meegan, Mary J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 23 p. 5612 - 5615
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium in tetrahydrofuran T=-78 - 5°C;
参考文献
Nikitin, Kirill V.; Andryukhova, Nonna P.
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 571 - 578
反应条件
potassium tert-butylate in tetrahydrofuran T=20°C; 2 h;
参考文献
Journal of the Chinese Chemical Society, , vol. 52, # 1 p. 159 - 167
反应条件
1: 82 percent / aq. NaOH; tetra-butylammonium bromide / 8 h / 20 °C 2: 58 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 52, # 1 p. 159 - 167
反应条件
1: potassium carbonate; acetone 2: Raney nickel; methanol / Hydrogenation.Erwaermen der Reaktionsloesung mit wss. Kalilauge 3: polyphosphoric acid View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 587, p. 38,47
反应条件
1: 1.) KOH, 2.) cc. HCl / 1.) ethanol, room temp., 1.5 h, 2.) water 2: 65 percent / polyphosphoric acid View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 65, p. 2575 - 2594
反应条件
1: Raney nickel; methanol / Hydrogenation.Erwaermen der Reaktionsloesung mit wss. Kalilauge 2: polyphosphoric acid View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 587, p. 38,47
反应条件
hydrogenchloride; mercury dichloride; zinc in water Ambient temperature;
参考文献
Lachapelle, A.; St-Jacques, M.
Canadian Journal of Chemistry, 1987 , vol. 65, p. 2575 - 2594
反应条件
sodium borohydride in methanol; ethyl acetate
参考文献
Hoechst Aktiengesellschaft
Patent: US5194442 A1, 1993 ;
