5-(氨基磺酰基)-N-(2,5-二氯戊基)-2-甲氧基苯甲酰胺合成路线 （共 3 条）
反应条件
1: 94.6 percent / NH3 / tetrahydrofuran / 0.5 h / Ambient temperature
2: 1.) ClCO2Et, Et3N, 2.) Et3N / 1.) acetone, 0 deg C, 0.5 h, 2.) 0 deg C, 0.5 h then r.t., 2.5 h
View Scheme
参考文献
Harrold, Marc W.; Wallace, Raye Ann; Farooqui, Tahira; Wallace, Lane J.; Uretsky, Norman; Miller, Duane D.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 874 - 880
反应条件
1: 84.9 percent / chlorosulfuric acid / 0.67 h / 60 - 70 °C
2: 94.6 percent / NH3 / tetrahydrofuran / 0.5 h / Ambient temperature
3: 1.) ClCO2Et, Et3N, 2.) Et3N / 1.) acetone, 0 deg C, 0.5 h, 2.) 0 deg C, 0.5 h then r.t., 2.5 h
View Scheme
参考文献
Harrold, Marc W.; Wallace, Raye Ann; Farooqui, Tahira; Wallace, Lane J.; Uretsky, Norman; Miller, Duane D.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 874 - 880
反应条件
chloroformic acid ethyl ester; triethylamine
1.) acetone, 0 deg C, 0.5 h, 2.) 0 deg C, 0.5 h then r.t., 2.5 h; Yield given. Multistep reaction;
参考文献
Harrold, Marc W.; Wallace, Raye Ann; Farooqui, Tahira; Wallace, Lane J.; Uretsky, Norman; Miller, Duane D.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 874 - 880
