2-疏基-7h-吡咯并[2,3-d]嘧啶-4-醇合成路线 （共 6 条）
参考文献
Reigan, Philip; Gbaj, Abdul; Chinje, Edwin; Stratford, Ian J.; Douglas, Kenneth T.; Freeman, Sally
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5247 - 5250
反应条件
1: 64 percent / NaOEt 2: 92 percent / aq. HCl View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 21 p. 5247 - 5250
反应条件
1: 81 percent / H2 / Raney Ni 2: 66 percent / POCl3 View Scheme
参考文献
Kim, Jiae; Wang, Ligong; Li, Yongfeng; Becnel, Kimberlynne D.; Frey, Kathleen M.; Garforth, Scott J.; Prasad, Vinayaka R.; Schinazi, Raymond F.; Liotta, Dennis C.; Anderson, Karen S.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4064 - 4067
反应条件
sodium methylate; nickel monoaluminide in methanol
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5753664 A1, 1998 ;
反应条件
1: 81 percent / H2 / Raney Ni 2: 66 percent / POCl3 3: 84 percent / H2 / Pd/C View Scheme
参考文献
Reigan, Philip; Gbaj, Abdul; Chinje, Edwin; Stratford, Ian J.; Douglas, Kenneth T.; Freeman, Sally
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5247 - 5250
反应条件
1: ammonium hydroxide / water / 72 h / Reflux 2: trichlorophosphate / 5 h / Reflux 3: N-iodo-succinimide / N,N-dimethyl-formamide / 20 h / Inert atmosphere; Darkness View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 4064 - 4067
