5-甲酰基噻吩-2-羧酸乙酯合成路线 （共 8 条）
反应条件
trifluoroacetic acid
T=90°C; Duff reaction; 3 h;
参考文献
Ahmed, S. Kaleem; Etoga, Jean-Louis G.; Patel, Sarjubhai A.; Bridges, Richard J.; Thompson, Charles M.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 14 p. 4358 - 4362
反应条件
1: thiophene-2-carboxylic acid ethyl ester With n-butyllithium; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; hexanes
T=-78 - 0°C; 0.166667 h; Inert atmosphere;
2: N,N-dimethyl-formamide T=-78 - 20°C;
参考文献
ELI LILLY AND COMPANY
Patent: EP1856090 B1, 2009 ;
Location in patent: Page/Page column 49; 57 ;
反应条件
hydrogenchloride; n-butyllithium; CO2 in tetrahydrofuran; diethyl ether; hexane
参考文献
SRI International
Patent: US4456618 A1, 1984 ;
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane
T=90°C; 3 h; Microwave irradiation;
参考文献
PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth, A.; OWENS, Tim, A.
Patent: WO2014/36016 A1, 2014 ;
Location in patent: Page/Page column 170; 171 ;
反应条件
sodium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Renouard, Thierry; Graetzel, Michael
Tetrahedron, 2001 , vol. 57, # 38 p. 8145 - 8150
反应条件
1: thiophene-2-carboxylic acid ethyl ester With chloromagnesium diisopropylamide in tetrahydrofuran
T=20°C; 0.166667 h;
2: 1-piperidinecarboxaldehyde in tetrahydrofuran
T=20°C; 30 h; Further stages.;
参考文献
Shilai, Manabu; Kondo, Yoshinori; Sakamoto, Takao
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 4 p. 442 - 444
反应条件
1: toluene / 120 °C
2: BuLi / tetrahydrofuran
3: 53 percent / Na2CO3 / dimethylformamide / 20 °C
View Scheme
参考文献
Renouard, Thierry; Graetzel, Michael
Tetrahedron, 2001 , vol. 57, # 38 p. 8145 - 8150
反应条件
1: BuLi / tetrahydrofuran
2: 53 percent / Na2CO3 / dimethylformamide / 20 °C
View Scheme
参考文献
Renouard, Thierry; Graetzel, Michael
Tetrahedron, 2001 , vol. 57, # 38 p. 8145 - 8150
