5-醛基噻吩-2-甲酸甲酯合成路线 （共 9 条）
反应条件
sodium carbonate in N,N-dimethyl-formamide Ambient temperature;
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 1 p. 17 - 28
反应条件
manganese(IV) oxide in acetone 48 h;
参考文献
CHONG KUN DANG PHARMACEUTICAL CORP.
Patent: WO2004/37808 A1, 2004 ;
Location in patent: Page 14-15; 93 ;
反应条件
1: 1-bromo-5-(1,3-dioxolan-2-yl)thiophene With n-butyllithium in tetrahydrofuran; hexane T=-78 - 70°C; 0.75 h; 2: methyl chloroformate in tetrahydrofuran 4 h; 3: With hydrogenchloride
参考文献
WO2004/13130 A1, ;
Page 203 ;
反应条件
thionyl chloride in methanol
参考文献
US5260296 A1, ;
US 5260296 A
反应条件
1: With pyridine T=100°C; 1.16667 h; 2: With water Further stages.;
参考文献
Augustine, John Kallikat; Naik, Y. Arthoba; Mandal, Ashis Baran; Chowdappa, Nagaraja; Praveen, Vinuthan B.
Tetrahedron, 2008 , vol. 64, # 4 p. 688 - 695
反应条件
potassium hydroxide; water in tetrahydrofuran
参考文献
CHONG KUN DANG PHARMACEUTICAL CORP.
Patent: WO2004/37808 A1, 2004 ;
Location in patent: Page 14-15; 93 ;
反应条件
jones reagent in acetone 1 h; Ambient temperature;
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 1 p. 17 - 28
反应条件
in ethyl acetate; acetone
参考文献
Pfizer Inc.
Patent: US5047554 A1, 1991 ;
US 5047554 A
反应条件
1: 73 percent / Jones reagent / acetone / 1 h / Ambient temperature
2: SOCl2 / 1.5 h / Heating
3: 2) HBr(g) / 1) ether, 0 deg C, overnight, 2) 20 min
View Scheme
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 1 p. 17 - 28
