4-叔丁基-2,6-二甲氧基苯酚合成路线 （共 6 条）
反应条件
sodium periodate in acetic acid
参考文献
Gierer,J.; Imsgard,F.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1977 , vol. 31, p. 537 - 545
反应条件
pyridine hydrochloride
参考文献
Fisons Limited
Patent: US4172960 A1, 1979 ;
反应条件
sodium; copper monoiodide in methanol; anhydrous xylene
参考文献
Fisons Limited
Patent: US4172960 A1, 1979 ;
反应条件
methanesulfonic acid
T=50°C; Alkylation; 3 h;
参考文献
Huffman, John W.; Liddle, John; Yu, Shu; Aung, Mie Mie; Abood, Mary E.; Wiley, Jenny L.; Martin, Billy R.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 12 p. 2905 - 2914
反应条件
sodium; copper monoiodide in N-methyl-acetamide; methanol
参考文献
Fisons Limited
Patent: US4172960 A1, 1979 ;
反应条件
1.1: NaH / tetrahydrofuran / 0.17 h / 0 °C
1.2: tetrahydrofuran / 0 - 20 °C
2.1: 3.5 g / Li; NH3 / tetrahydrofuran; diethyl ether / 1.5 h / -78 °C
3.1: 100 percent / BBr3 / CH2Cl2 / 18 h / 25 °C
View Scheme
参考文献
Pop, Emil; Browne, Clinton E.; Nadler, Varda; Biegon, Anat; Brewster, Marcus E.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 13 p. 1553 - 1558
