N-[(2S,3R)-3-氨基-2-羟基-5-甲基-1-氧代己基]-L-缬氨酰-L-缬氨酰-L-天冬氨酸合成路线 （共 11 条）
反应条件
1: DCC, HOBt, Et3N
2: TFA
3: DCC, HOBt, Et3N
4: TFA
5: DCC, HOBt, Et3N
6: H2 / Pd-C
View Scheme
参考文献
Tobe; Morishima; Aoyagi; et al.
Agricultural and Biological Chemistry, 1982 , vol. 46, # 7 p. 1865 - 1872
反应条件
1: 1.) NaHSO3 / 1.) 5 deg C, overnight, 2.) ethyl acetate, water, room temp., 4 h
2: 90 percent / concentrated HCl / dioxane / 12 h / Heating
3: 73 percent / triethylamine / H2O; dioxane / 25 °C
4: 1.) hydrochloric acid, 2.) triethylamine, DCC, HOBt / 1.) dioxane, 30 min, 25 deg C 2.) methylene chloride
5: 1.) TFA, 2.) H2, Pd/C / 1.) room temperature, 30 min 2.) methanol, 24 h
View Scheme
参考文献
Rich, Daniel H.; Moon, Byung Jo; Boparai, Amrit S.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2288 - 2290
反应条件
1: 90 percent / concentrated HCl / dioxane / 12 h / Heating
2: 73 percent / triethylamine / H2O; dioxane / 25 °C
3: 1.) hydrochloric acid, 2.) triethylamine, DCC, HOBt / 1.) dioxane, 30 min, 25 deg C 2.) methylene chloride
4: 1.) TFA, 2.) H2, Pd/C / 1.) room temperature, 30 min 2.) methanol, 24 h
View Scheme
参考文献
Rich, Daniel H.; Moon, Byung Jo; Boparai, Amrit S.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2288 - 2290
反应条件
1: 73 percent / triethylamine / H2O; dioxane / 25 °C
2: 1.) hydrochloric acid, 2.) triethylamine, DCC, HOBt / 1.) dioxane, 30 min, 25 deg C 2.) methylene chloride
3: 1.) TFA, 2.) H2, Pd/C / 1.) room temperature, 30 min 2.) methanol, 24 h
View Scheme
参考文献
Rich, Daniel H.; Moon, Byung Jo; Boparai, Amrit S.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2288 - 2290
反应条件
1: Diisobutylaluminum hydride / toluene / 0.1 h / -78 °C
2: 1.) NaHSO3 / 1.) 5 deg C, overnight, 2.) ethyl acetate, water, room temp., 4 h
3: 90 percent / concentrated HCl / dioxane / 12 h / Heating
4: 73 percent / triethylamine / H2O; dioxane / 25 °C
5: 1.) hydrochloric acid, 2.) triethylamine, DCC, HOBt / 1.) dioxane, 30 min, 25 deg C 2.) methylene chloride
6: 1.) TFA, 2.) H2, Pd/C / 1.) room temperature, 30 min 2.) methanol, 24 h
View Scheme
参考文献
Rich, Daniel H.; Moon, Byung Jo; Boparai, Amrit S.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2288 - 2290
反应条件
1: TFA
2: DCC, HOBt, Et3N
3: TFA
4: DCC, HOBt, Et3N
5: H2 / Pd-C
View Scheme
参考文献
Tobe; Morishima; Aoyagi; et al.
Agricultural and Biological Chemistry, 1982 , vol. 46, # 7 p. 1865 - 1872
反应条件
1: TFA
2: DCC, HOBt, Et3N
3: H2 / Pd-C
View Scheme
参考文献
Tobe; Morishima; Aoyagi; et al.
Agricultural and Biological Chemistry, 1982 , vol. 46, # 7 p. 1865 - 1872
反应条件
1: DCC, HOBt, Et3N
2: TFA
3: DCC, HOBt, Et3N
4: H2 / Pd-C
View Scheme
参考文献
Tobe; Morishima; Aoyagi; et al.
Agricultural and Biological Chemistry, 1982 , vol. 46, # 7 p. 1865 - 1872
反应条件
1: DCC, HOBt, Et3N
2: H2 / Pd-C
View Scheme
参考文献
Tobe; Morishima; Aoyagi; et al.
Agricultural and Biological Chemistry, 1982 , vol. 46, # 7 p. 1865 - 1872
反应条件
palladium on activated charcoal; hydrogen; trifluoroacetic acid
1.) room temperature, 30 min 2.) methanol, 24 h; Yield given. Multistep reaction;
参考文献
Rich, Daniel H.; Moon, Byung Jo; Boparai, Amrit S.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2288 - 2290
