反应条件
1: 1,1-dimethylethyl 1,4-dioxo-8-azaspiro[4.5]-8-carboxylate With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran
T=-78°C; 2 h;
2: methyl iodide in tetrahydrofuran
T=-78 - 20°C; 16 h;
参考文献
Wang, Tao; Kadow, John F.; Meanwell, Nicholas A.; Yeung, Kap-Sun; Zhang, Zhongxing; Yin, Zhiwei; Qiu, Zhilei; Deon, Daniel H.; James, Clint A.; Ruediger, Edward H.; Bachand, Carol
Patent: US2004/63744 A1, 2004 ;
Location in patent: Page/Page column 72-73 ;