2-(氯甲基)-3-乙基-3H-咪唑并4,5-c吡啶盐酸盐合成路线 （共 8 条）
反应条件
trifluoroacetic acid in dichloromethane
T=30°C; 72 h;
参考文献
Pfizer Inc
Patent: US2004/63938 A1, 2004 ;
Location in patent: Page 9 ;
US 20040063938 A1
反应条件
in ethyl acetate
T=20°C; 16 h;
参考文献
Pfizer Inc
Patent: US2004/63938 A1, 2004 ;
Location in patent: Page 8 ;
US 20040063938 A1
反应条件
trifluoroacetic acid in dichloromethane
T=30°C; 72 h;
参考文献
Caron, Stephane; Do, Nga M.; McDermott, Ruth E.; Bahmanyar
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 257 - 261
反应条件
1: dichloromethane / 20 °C
2: ethanol / 0 - 20 °C
3: sodium tetrahydroborate; ethanol / 10 h / 0 - 20 °C
4: trifluoroacetic acid / dichloromethane / 72 h / 30 °C
View Scheme
参考文献
Caron, Stephane; Do, Nga M.; McDermott, Ruth E.; Bahmanyar
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 257 - 261
反应条件
1: ethanol / 0 - 20 °C
2: sodium tetrahydroborate; ethanol / 10 h / 0 - 20 °C
3: trifluoroacetic acid / dichloromethane / 72 h / 30 °C
View Scheme
参考文献
Caron, Stephane; Do, Nga M.; McDermott, Ruth E.; Bahmanyar
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 257 - 261
反应条件
hydrogenchloride in isopropyl alcohol
参考文献
Caron, Stephane; Do, Nga M.; McDermott, Ruth E.; Bahmanyar
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 257 - 261
反应条件
1: ethyl acetate / 16 h / |Inert atmosphere
2: hydrogenchloride / isopropyl alcohol
View Scheme
参考文献
Caron, Stephane; Do, Nga M.; McDermott, Ruth E.; Bahmanyar
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 257 - 261
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 20 - 25 °C / |Inert atmosphere
2: ethyl acetate / 16 h / |Inert atmosphere
3: hydrogenchloride / isopropyl alcohol
View Scheme
参考文献
Caron, Stephane; Do, Nga M.; McDermott, Ruth E.; Bahmanyar
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 257 - 261
