4-溴吲哚-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran 0.25 h;
参考文献
Roche Palo Alto LLC
Patent: US2004/72844 A1, 2004 ;
Location in patent: Page/Page column 13-14 ;
US 20040072844 A1
反应条件
sodium hydride in tetrahydrofuran; mineral oil 22 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/50659 A1, 2004 ;
Location in patent: Page 95-96 ;
WO 2004/050659 A1
反应条件
sodium hydride in tetrahydrofuran 18 h;
参考文献
WO2006/66172 A1, ;
Page/Page column 78-79 ;
WO 2006/066172 A1
反应条件
tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; tri-isobutyl aluminium; butanone; potassium bromide in toluene T=100°C; 24 h; Inert atmosphere;
参考文献
Shen, Xiaoqiang; Hyde, Alan M.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2010 , vol. 132, # 40 p. 14076 - 14078
反应条件
1: With tri-isopropoxy-borane; lithium diisopropyl amide in tetrahydrofuran T=0 - 5°C; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Zhou, Jiao-Long; Ye, Meng-Chun; Sun, Xiu-Li; Tang, Yong
Tetrahedron, 2009 , vol. 65, # 34 p. 6877 - 6881
反应条件
tetrakis(triphenylphosphine) palladium(0); cesium fluoride in 1,2-dichloro-ethane
T=75°C; 6 h; Inert atmosphereSealed tube;
参考文献
Ramgren, Stephen D.; Garg, Neil K.
Organic Letters, 2014 , vol. 16, # 3 p. 824 - 827
