7-羟基-3,4-二氢-1(2H)-喹啉羧酸叔丁酯合成路线 （共 4 条）
反应条件
potassium carbonate in methanol
T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/26837 A2, 2004 ;
Location in patent: Page 13-14 ;
WO 2004/026837 A2
反应条件
triethylamine in dichloromethane
T=45°C; 48 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2008/58867 A2, 2008 ;
Location in patent: Page/Page column 33-34 ;
WO 2008/058867 A2
反应条件
1: H2 / PtO2 / methanol / 3102.89 Torr
2: BBr3 / CH2Cl2 / -78 °C
3: NaOH / dioxane
View Scheme
参考文献
Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3415 - 3418
反应条件
1: BBr3 / CH2Cl2 / -78 °C
2: NaOH / dioxane
View Scheme
参考文献
Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3415 - 3418
