N-[2-(3,4-二甲氧基苯基)乙基]苯甲酰胺合成路线 （共 13 条）
反应条件
1: 72 percent / P2O5, POCl3 / xylene / 6 h / Heating 2: 74 percent / acetic acid, NaBH4 / methanol / 1.) RT, 1 h, 2.) 50 deg C, 4 h View Scheme
参考文献
Minor, Deborah L.; Wyrick, Steven D.; Charifson, Paul S.; Watts, Val J.; Nichols, David E.; Mailman, Richard B.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4317 - 4328
反应条件
trichlorophosphate in toluene 1 h; Heating;
参考文献
Glusa; Gruner; Hagen; Lohmann; Foken
Pharmazie, 1990 , vol. 45, # 6 p. 408 - 410
反应条件
1: 60 percent / Et3N, DMAP / CH2Cl2 / Heating 2: 95 percent / n-BuLi / tetrahydrofuran; hexane / a) 0 deg C, 75 min, b) RT, overnight 3: 84 percent / LiAlH4 / tetrahydrofuran / 6 h / Heating 4: 1.) n-BuLi, 2.) n-BuLi View Scheme
参考文献
Lete, Esther; Collado, M. Isabel; Sotomayor, Nuria; Vicente, Teresa; Villa, Maria-Jesus
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1751 - 1758
反应条件
trichlorophosphate in toluene 3.5 h; Heating; Yield given;
参考文献
Barker, John M.; Huddleston, Patrick R.; Clephane, Janette; Wood, Michael L.; Holmes, David
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 275 - 282
反应条件
sodium hydroxide in diethyl ether
Ambient temperature;
参考文献
Minor, Deborah L.; Wyrick, Steven D.; Charifson, Paul S.; Watts, Val J.; Nichols, David E.; Mailman, Richard B.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4317 - 4328
反应条件
tetra-(n-butyl)ammonium iodide in dichloromethane
Ambient temperatureelectrolyzed at -1.7 V at 50 mA;
参考文献
Arai, Kenji; Shaw, Chu-hei; Nozawa, Koohei; Kawai, Ken-ichi; Nakajima, Shoichi
Tetrahedron Letters, 1987 , vol. 28, # 4 p. 441 - 442
反应条件
1: With potassium phosphate; sodium iodide in sulfolane
T=20 - 35°C; Inert atmosphere;
2: With tert.-butylhydroperoxide in sulfolane; decane
T=30 - 35°C; Inert atmosphere;
参考文献
Shankar; More, Satish S.; Madhubabu; Vembu; Syam Kumar
Synlett, 2012 , vol. 23, # 7 p. 1013 - 1020
反应条件
silica gel; toluene-4-sulfonic acid
0.0333333 h; microwave irradiation;
参考文献
Hajipour; Ghasemi
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 6 p. 504 - 507
反应条件
acetic acid; platinum
Hydrogenation;
参考文献
Sugasawa
Yakugaku Zasshi, 1935 , vol. 55, p. 224,228; engl. Ref. S. 58, 59
Chem.Abstr., 1935 , p. 5116
参考文献
Glusa; Gruner; Hagen; Lohmann; Foken
Pharmazie, 1990 , vol. 45, # 6 p. 408 - 410
