5-溴-2-氯-3-硝基吡啶合成路线 （共 46 条）
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/129044 A1, 2007 ;
Location in patent: Page/Page column 77 ;
WO 2007/129044 A1
反应条件
1: With N,N-dimethyl-formamide; trichlorophosphate 3 h; Heating / reflux; 2: With sodium hydrogencarbonate in diethyl ether
参考文献
PFIZER JAPAN INC.; PFIZER INC.
Patent: WO2007/102059 A1, 2007 ;
Location in patent: Page/Page column 45 ;
反应条件
thionyl chloride in toluene
参考文献
US6465484 B1, ;
US 6465484 B1
反应条件
phosphorus pentachloride; trichlorophosphate
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6200976 B1, 2001 ;
US 6200976 B1
反应条件
in chloroform; trichlorophosphate
参考文献
US4665078 A1, ;
US 4665078 A
反应条件
1: nitric acid; sulfuric acid / 0 - 20 °C / |Inert atmosphere 2: sulfuric acid; sodium nitrite / water / 0 - 20 °C / |Inert atmosphere 3: trichlorophosphate / N,N-dimethyl-formamide / 12 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 5 p. 1077 - 1083
反应条件
sodium hydride in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
Hameed P., Shahul; Shanbhag, Gajanan; Shinde, Vikas; Chinnapattu, Murugan; Manjrekar, Praveena; Puttur, Jayashree; Patil, Vikas; Ugarkar, Bheemarao
Synthetic Communications, 2013 , vol. 43, # 24 p. 3315 - 3321
参考文献
Heilmann, Dieter; Siehr, Ilona; Beerbalk, Hans-Dieter; Kempter, Gerhard; Koeppel, Hubert
Zeitschrift fuer Chemie (Stuttgart, Germany), 1986 , vol. 26, # 3 p. 99
反应条件
2: ethanol; water; ethyl acetate 3: pyridine View Scheme
参考文献
Calitor Sciences, LLC; Xi, Ning
Patent: US2014/134133 A1, 2014 ;
反应条件
1: methanol / 0 - 20 °C 2: SnCl2·2H2O / ethyl acetate / 4 h / Reflux 3: pyridine / 0 - 20 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; VEEN, Van Der, Lars; KRAEMER, Oliver
Patent: WO2012/101186 A1, 2012 ;
WO 2012/101186 A1
