2-(3-溴苯基)-1,3-二恶烷合成路线 （共 5 条）
反应条件
1: Pd2(dba)3; rac-BINAP; NaOtBu / toluene / 18 h / 100 °C 2: 17 g / aq. HCl / toluene / 2 h / 25 °C View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, from -100 deg C to -78 deg C, 1 h 25 min, 2.) hexane, THF, -70 deg C, 1 h 2: 93 percent / LiAlH4 / diethyl ether / 2 h / 0 °C View Scheme
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
n-butyllithium 1.) hexane, THF, from -100 deg C to -78 deg C, 1 h 25 min, 2.) hexane, THF, -70 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Ackerley, Norman; Brewster, Andrew G.; Brown, George R.; Clarke, David S.; Foubister, Alan J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1608 - 1628
反应条件
toluene-4-sulfonic acid in toluene
15.5 h; RefluxDean-Stark;
参考文献
RVX Therapeutics Inc.; Fairfax, David John; Duffy, Bryan Cordell; Martin, Gregory Scott; Quinn, John Frederick; Liu, Shuang; Wagner, Gregory Steven; Young, Peter Ronald
Patent: US2014/142102 A1, 2014 ;
Location in patent: Paragraph 0590; 0591 ;
反应条件
1: Pd2(dba)3; rac-BINAP; NaOtBu / toluene / 18 h / 100 °C
2: 17 g / aq. HCl / toluene / 2 h / 25 °C
3: 95 percent / NBS / CH2Cl2 / 0.17 h / 20 °C
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
