4-氯-5,6-二甲基嘧啶合成路线 （共 7 条）
反应条件
caesium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide; toluene T=140°C; 1 h; Irradiation;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/3997 A1, 2009 ;
Location in patent: Page/Page column 20-21 ;
WO 2009/003997 A1
反应条件
thionyl chloride in N-methyl-acetamide; acetonitrile
反应条件
1: aqueous H2O2 / 70 - 90 °C 2: POCl3 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 59, p. 526,527
反应条件
1: ethanol 2: POCl3 View Scheme
参考文献
Journal of the Chemical Society, , p. 362,365
反应条件
T=550°C; Yield given. Yields of byproduct given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1427 - 1430
反应条件
1: With N-(diphenylmethylene)amine; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene
T=80°C; 1 h;
2: With hydrogenchloride in tetrahydrofuran; water
T=20°C; 3 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/3997 A1, 2009 ;
Location in patent: Page/Page column 21 ;
WO 2009/003997 A1
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813
