4-氨基-1-BETA-D-呋喃核糖基-1H-咪唑并[4,5-C]吡啶合成路线 （共 17 条）
反应条件
Amberlite IRA 900 fluoride-form in toluene 6 h; Heating;
参考文献
Erlacher, Matthias D.; Lang, Kathrin; Wotzel, Brigitte; Rieder, Renate; Micura, Ronald; Polacek, Norbert
Journal of the American Chemical Society, 2006 , vol. 128, # 13 p. 4453 - 4459
反应条件
dipotassium hydrogenphosphate in water T=37°C; 72 h; uridine phosphorylase, purine nucleoside phosphorylase;
参考文献
Krenitsky; Rideout; Chao; Koszalka; Gurney; Crouch; Cohn; Wolberg; Vinegar
Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 138 - 143
反应条件
phosphate buffer; purine nucleoside phosphorylase in water T=25°C; 48 h; pH 7.0-7.4;
参考文献
Hennen; Wong
Journal of Organic Chemistry, 1989 , vol. 54, # 19 p. 4692 - 4695
反应条件
purine nucleoside phosphorylase in water T=25°C; 48 h; pH 7.0-7.4;
参考文献
Hennen; Wong
Journal of Organic Chemistry, 1989 , vol. 54, # 19 p. 4692 - 4695
反应条件
phosphate buffer; purine nucleoside phosphorylase in water T=25°C; 48 h; pH 7.0-7.4;
参考文献
Hennen; Wong
Journal of Organic Chemistry, 1989 , vol. 54, # 19 p. 4692 - 4695
反应条件
ammonia in methanol T=120°C; 3 h;
参考文献
Tetrahedron, , vol. 49, # 3 p. 557 - 570
反应条件
1.1: Pd(PhCN)2Cl2; Et3N / acetonitrile / 20 h / 110 °C 1.2: 50 percent / NH3; methanol / 14 h / 120 °C 2.1: 79 percent / Amberlite IRA 900 fluoride-form / toluene / 6 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 13 p. 4453 - 4459
反应条件
1.1: 60 percent / diiodomethane; isoamyl nitrite / 0.75 h / 100 °C 2.1: Pd(PhCN)2Cl2; Et3N / acetonitrile / 20 h / 110 °C 2.2: 50 percent / NH3; methanol / 14 h / 120 °C 3.1: 79 percent / Amberlite IRA 900 fluoride-form / toluene / 6 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 13 p. 4453 - 4459
反应条件
1.1: 70 percent / ethylenediamine / 6 h / 50 °C 2.1: 95 percent / p-toluenesulfonyl chloride; pyridine / 20 h / 20 °C 3.1: 60 percent / diiodomethane; isoamyl nitrite / 0.75 h / 100 °C 4.1: Pd(PhCN)2Cl2; Et3N / acetonitrile / 20 h / 110 °C 4.2: 50 percent / NH3; methanol / 14 h / 120 °C 5.1: 79 percent / Amberlite IRA 900 fluoride-form / toluene / 6 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 13 p. 4453 - 4459
反应条件
1.1: 3.52 g / K2CO3 / dimethylformamide / 2.5 h / 80 °C 2.1: 70 percent / ethylenediamine / 6 h / 50 °C 3.1: 95 percent / p-toluenesulfonyl chloride; pyridine / 20 h / 20 °C 4.1: 60 percent / diiodomethane; isoamyl nitrite / 0.75 h / 100 °C 5.1: Pd(PhCN)2Cl2; Et3N / acetonitrile / 20 h / 110 °C 5.2: 50 percent / NH3; methanol / 14 h / 120 °C 6.1: 79 percent / Amberlite IRA 900 fluoride-form / toluene / 6 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 13 p. 4453 - 4459
