2-羟基-2-苯基乙基氨基甲酸叔丁酯合成路线 （共 9 条）
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
F. HOFFMANN-LA ROCHE AG; LIU, Wenjian; LUK, Kin-Chun Thomas; ZHANG, Xiaohu
Patent: WO2012/98068 A1, 2012 ;
Location in patent: Page/Page column 20-21 ;
反应条件
polymethylhydrosiloxane; palladium on activated charcoal in ethanol
T=20°C; Carboxylation; 4 h;
参考文献
Chandrasekhar; Chandraiah; Raji Reddy; Venkat Reddy
Chemistry Letters, 2000 , # 7 p. 780 - 781
反应条件
triethylamine in dichloromethane; di-isopropyl ether; water
参考文献
Sankyo Company, Limited
Patent: US4699905 A1, 1987 ;
US 4699905 A
反应条件
K2OsO4*2H2O; water in tert-butyl alcohol
T=0 - 20°C; regioselective reaction;
参考文献
Masruri; Willis, Anthony C.; McLeod, Malcolm D.
Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8480 - 8491
反应条件
caesium carbonate in methanol
1 h; Ambient temperature;
参考文献
Ishizuka, Tadao; Kunieda, Takehisa
Tetrahedron Letters, 1987 , vol. 28, # 36 p. 4185 - 4188
反应条件
sodium hydroxide; (DHQD)2PHAL; potassium dioxotetrahydroxoosmate(VI); tert-butylhypochlorite
1.) n-PrOH, H2O, 5 min, 2.) n-PrOH, H2O, 0 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
O'Brien, Peter; Osborne, Simon A.; Parker, Daniel D.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 16 p. 2519 - 2526
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: K2OsO4*2H2O; water / tert-butyl alcohol / 0 - 20 °C
View Scheme
参考文献
Masruri; Willis, Anthony C.; McLeod, Malcolm D.
Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8480 - 8491
反应条件
(i) AgNO3, MeCN, (ii) aq. OsO4, tBuOH; Multistep reaction;
参考文献
Herranz,E. et al.
Journal of the American Chemical Society, 1978 , vol. 100, p. 3596 - 3598
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide
T=20°C; 21 h;
参考文献
Miyata, Sachiho; Kumamoto, Takuya; Ishikawa, Tsutomu
Helvetica Chimica Acta, 2007 , vol. 90, # 7 p. 1420 - 1438
