12-(t-叔丁氧羰基-氨基)-1-十二烷醇合成路线 （共 10 条）
反应条件
iPr2Net in pyridine
T=78°C; 60 h; Inert atmosphere;
参考文献
Colorobbia Italia S.p.a.
Patent: EP1979365 B1, 2012 ;
Location in patent: Page/Page column 6-7 ;
反应条件
triethylamine in tetrahydrofuran
2 h; Ambient temperature;
参考文献
Kleuser, Burkhard; Schmidt, Norbert; Gercken, Guenther
Chemistry and Physics of Lipids, 1993 , vol. 66, # 1-2 p. 111 - 122
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in tetrahydrofuran; toluene
1 h;
参考文献
Forbes, Christopher C.; DiVittorio, Kristy M.; Smith, Bradley D.
Journal of the American Chemical Society, 2006 , vol. 128, # 28 p. 9211 - 9218
反应条件
1: 90 percent / triethylamine / methanol / 60 °C
2: 84 percent / Red-Al / tetrahydrofuran; toluene / 1 h
View Scheme
参考文献
Forbes, Christopher C.; DiVittorio, Kristy M.; Smith, Bradley D.
Journal of the American Chemical Society, 2006 , vol. 128, # 28 p. 9211 - 9218
反应条件
1: 90 percent / triethylamine / methanol / 60 °C
2: 84 percent / Red-Al / tetrahydrofuran; toluene / 1 h
View Scheme
参考文献
Forbes, Christopher C.; DiVittorio, Kristy M.; Smith, Bradley D.
Journal of the American Chemical Society, 2006 , vol. 128, # 28 p. 9211 - 9218
反应条件
sodium tetrahydroborate in ethylene glycol dimethyl ether
参考文献
Brouwer, Arwin J.; Mulders, Suzanne J. E.; Liskamp, Rob M. J.
European Journal of Organic Chemistry, 2001 , # 10 p. 1903 - 1915
反应条件
1: NaOH
2: NaBH4 / 1,2-dimethoxy-ethane
View Scheme
参考文献
Brouwer, Arwin J.; Mulders, Suzanne J. E.; Liskamp, Rob M. J.
European Journal of Organic Chemistry, 2001 , # 10 p. 1903 - 1915
反应条件
1: 93 percent / dimethylsulfoxide / 0.5 h / 90 °C
2: 74 percent / sodium aluminum bis-(2-methoxyethoxo)-dihydrode (Vitrid) / diethyl ether; toluene / 2 h / Heating
3: 99 percent / Et3N / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Kleuser, Burkhard; Schmidt, Norbert; Gercken, Guenther
Chemistry and Physics of Lipids, 1993 , vol. 66, # 1-2 p. 111 - 122
反应条件
1: 74 percent / sodium aluminum bis-(2-methoxyethoxo)-dihydrode (Vitrid) / diethyl ether; toluene / 2 h / Heating
2: 99 percent / Et3N / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Kleuser, Burkhard; Schmidt, Norbert; Gercken, Guenther
Chemistry and Physics of Lipids, 1993 , vol. 66, # 1-2 p. 111 - 122
反应条件
N-bromosuccinmide; triphenylphosphine in dichloromethane
24 h; RefluxInert atmosphere;
参考文献
Colorobbia Italia S.p.a.
Patent: EP1979365 B1, 2012 ;
Location in patent: Page/Page column 7 ;
