2-氯-3,4-二甲氧基苯乙胺合成路线 （共 18 条）
反应条件
diborane in tetrahydrofuran
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: With AlCl3, aluminium chloride; lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 16.66 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
Location in patent: Page/Page column 74; 75 ;
反应条件
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 2: 97 percent / 12N aq. HCl 3: 96 percent / dimethylsulfoxide / 1.25 h 4: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 90 percent / Cl2 2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 3: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 4: 97 percent / 12N aq. HCl 5: 96 percent / dimethylsulfoxide / 1.25 h 6: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 96 percent / dimethylsulfoxide / 1.25 h 2: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating 2: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 3: 97 percent / 12N aq. HCl 4: 96 percent / dimethylsulfoxide / 1.25 h 5: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 97 percent / 12N aq. HCl 2: 96 percent / dimethylsulfoxide / 1.25 h 3: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 44 percent 2: 85 percent / H2SO4 / trifluoroacetic acid / Heating 3: BBr3 / CH2Cl2 View Scheme
参考文献
Weinstock; Wilson; Ladd; Brush; Pfeiffer; Kuo; Holden; Yim; Hahn; Wardell Jr.; Tobia; Setler; Sarau; Ridley
Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 973 - 975
反应条件
1: 19 percent / 2.5 h / Heating 2: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 19 percent / 2.5 h / Heating 2: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C 3: 95 percent / BBr3 / CH2Cl2 / 3 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
