N-(2-(3,4-二甲氧基苯基)乙基)-2-(3-甲氧基苯基)乙酰胺合成路线 （共 6 条）
反应条件
sodium hydroxide in dichloromethane; water
T=0 - 20°C; Schotten-Baumann Reaction; 3 h;
参考文献
Parraga, Javier; Cabedo, Nuria; Andujar, Sebastian; Piqueras, Laura; Moreno, Laura; Galan, Abraham; Angelina, Emilio; Enriz, Ricardo D.; Ivorra, Maria Dolores; Sanz, Maria Jesus; Cortes, Diego
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 150 - 166
反应条件
1: (3-methoxy-phenyl)-acetic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 0.5 h;
2: 2-(3,4-dimethoxyphenyl)-ethylamine in dichloromethane
T=20°C; 8 h;
参考文献
Qian, Wangke; Lu, Weijian; Sun, Haifeng; Li, Zeng; Zhu, Liyuan; Zhao, Rui; Zhang, Lei; Zhou, Shengbin; Zhou, Yu; Jiang, Hualiang; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4862 - 4871
反应条件
1: thionyl chloride / CH2Cl2
2: 85 percent / CH2Cl2
View Scheme
参考文献
Kuo, Reen-Yen; Wu, Chin-Chung; Chang, Fang-Rong; Yeh, Jwu-Lai; Chen, Ing-Jun; Wu, Yang-Chang
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 5 p. 821 - 823
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux
1.2: 0 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C
2.2: 8 h / 20 °C
View Scheme
参考文献
Qian, Wangke; Lu, Weijian; Sun, Haifeng; Li, Zeng; Zhu, Liyuan; Zhao, Rui; Zhang, Lei; Zhou, Shengbin; Zhou, Yu; Jiang, Hualiang; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4862 - 4871
反应条件
1.1: ammonium acetate; acetic acid / 4 h / 90 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux
2.2: 0 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C
3.2: 8 h / 20 °C
View Scheme
参考文献
Qian, Wangke; Lu, Weijian; Sun, Haifeng; Li, Zeng; Zhu, Liyuan; Zhao, Rui; Zhang, Lei; Zhou, Shengbin; Zhou, Yu; Jiang, Hualiang; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4862 - 4871
反应条件
1: aqueous H2SO4; aqueous acetic acid / Erhitzen des Reaktionsprodukts mit Raney-Nickel und wss. NaOH
2: 200 °C
View Scheme
参考文献
Shepard et al.
Journal of Organic Chemistry, 1952 , vol. 17, p. 568,570
