O-(四氢吡喃-2-基)羟胺合成路线 （共 3 条）
反应条件
hydrazine in methanol T=60°C; 0.5 h;
参考文献
CRYSTAL BIOPHARMACEUTICAL LLC; CHEN, Yi; CHEN, Yu
Patent: WO2012/96832 A2, 2012 ;
Location in patent: Page/Page column 37-38 ;
WO 2012/096832 A2
反应条件
1: With 2-hydroxy-1,3-isoindolinedione; toluene-4-sulfonic acid in 1,4-dioxane; dichloromethane 2 h; 2: With methylhydrazine in benzene T=80°C; 0.25 h;
参考文献
Martin, Nathaniel I.; Woodward, Joshua J.; Marietta, Michael A.
Organic Letters, 2006 , vol. 8, # 18 p. 4035 - 4038
反应条件
acetic acid in toluene T=115°C; P=4500.45 Torr; 0.216667 h; Microwave irradiation;
参考文献
Kurz, Thomas; Pein, Miriam K.; Marek, Linda; Behrendt, Christoph T.; Spanier, Lukas; Kuna, Krystina; Bruecher, Karin
European Journal of Organic Chemistry, 2009 , # 18 p. 2939 - 2942
