3,3-二甲基-1-苯基-2-丁酮合成路线 （共 50 条）
反应条件
(C5Me5)2Sm(tetrahydrofuran)
1) toluene, rt, 24 h; 2) toluene, rt, 24 h; Yield given. Multistep reaction;
参考文献
Takaki, Ken; Maruo, Masafumi; Kamata, Tohru; Makioka, Yoshikazu; Fujiwara, Yuzo
Journal of Organic Chemistry, 1996 , vol. 61, # 23 p. 8332 - 8334
反应条件
in dimethyl sulfoxide
T=35°C; 1.3 h; Irradiationother solvent, time, temperature; Product distribution;
参考文献
Semmelhack, M. F.; Bargar, Thomas
Journal of the American Chemical Society, 1980 , vol. 102, # 26 p. 7765 - 7774
反应条件
water; silica gel
1) THF, -70 deg C, gradual warming, 1 h, 2) hexane; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Marks, Maurice J.; Walborsky, Harry M.
Journal of Organic Chemistry, 1981 , vol. 46, # 26 p. 5405 - 5407
反应条件
1: 75 percent / Et3N
2: 32 percent / Li; naphthalene / 1 h / -78 - 0 °C
View Scheme
参考文献
Alonso, Emma; Guijarro, David; Martinez, Pedro; Ramon, Diego J.; Yus, Miguel
Tetrahedron, 1999 , vol. 55, # 36 p. 11027 - 11038
反应条件
1: 3,3-dimethyl-butan-2-one With potassium tert-butylate in dimethyl sulfoxide
0.166667 h; Inert atmosphere;
2: iodobenzene; 2-(2-iodophenyl)acetic acid in dimethyl sulfoxide
0.0833333 h; Inert atmosphereIrradiation;
3: With ammonium nitrate; nitric acid in water
参考文献
Guastavino, Javier F.; Buden, Maria E.; Garcia, Carolina S.; Rossi, Roberto A.
Arkivoc, 2011 , vol. 2011, # 7 p. 389 - 405
反应条件
potassium tert-butylate
1) DMSO, 2) RT, 120 min; Yield given. Multistep reaction;
参考文献
Dell'Erba, Carlo; Novi, Marino; Petrillo, Giovanni; Tavani, Cinzia
Tetrahedron, 1992 , vol. 48, # 2 p. 325 - 334
反应条件
(.eta.5-C5H5)2Sm
1) THF, 45 min, room temperature, 2) -30 deg C, THF, 1 h; Yield given. Multistep reaction;
参考文献
Bied; Collin; Kagan
Tetrahedron, 1992 , vol. 48, # 19 p. 3877 - 3890
参考文献
Kauffmann,T.; Sobel,J.
Chemische Berichte, 1966 , vol. 99, p. 1843 - 1850
反应条件
copper; magnesium; copper(l) chloride
1)ether 2) 0 deg C,1h; Yield given. Multistep reaction;
参考文献
Montignoul, Claude; Richard, Marie-Josee; Vigne, Christian; Giral, Louis
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1509 - 1519
反应条件
2: (i) NaNHNH2, (ii) H2O
3: aq. AcOH
4: aq. H2SO4
View Scheme
参考文献
Kauffmann,T.; Sobel,J.
Chemische Berichte, 1966 , vol. 99, p. 1843 - 1850
