4-氨基-6-三氟甲基嘧啶合成路线 （共 5 条）
反应条件
ammonia in water; acetonitrile T=25°C; 12 h;
参考文献
ASTRAZENECA AB
Patent: US2009/170849 A1, 2009 ;
Location in patent: Page/Page column 14 ;
US 20090170849 A1
反应条件
1: 6-trifluoromethyl-4-hydroxypyrimidine With oxalyl dichloride; N,N-dimethyl-formamide in ethyl acetate 2 h; Reflux; 2: ammonia in methanol T=70°C; 15 h; Sealed tube;
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHANG, Deyi; ZHANG, Ruihao; ZHONG, Boyu; SHIH, Chuan
Patent: WO2014/418 A1, 2014 ;
Location in patent: Page/Page column 84 ;
反应条件
1: With trichlorophosphate 7 h; Heating / reflux; 2: With ammonia in water T=20°C;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2007/75650 A2, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
1: Raney nickel; aqueous NH3 2: POCl3; N,N-diethyl-aniline / anschliessendes Behandeln mit aethanol.NH3 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 80, p. 5744,5751
参考文献
Journal of the American Chemical Society, , vol. 80, p. 5744,5751
