1-苄基-2-吡咯烷甲醇合成路线 （共 13 条）
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran T=0 - 20°C; Appel Halogenation; 16 h;
参考文献
Purohit, Meena K.; Chakka, Sai Kumar; Scovell, Iain; Neschadim, Anton; Bello, Angelica M.; Salum, Norue; Katsman, Yulia; Bareau, Madeleine C.; Branch, Donald R.; Kotra, Lakshmi P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 9 p. 2739 - 2752
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 4 h; Cooling with ice;
参考文献
ENDO PHARMACEUTICALS INC.; GUPTA, Sandeep; PRIESTLEY, Tony; LAPING, Nicholas, James
Patent: WO2014/28675 A1, 2014 ;
Location in patent: Page/Page column 118-119 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
4 h; Heating;
参考文献
Kurkin; Karchava; Yurovskaya
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 10 p. 1141 - 1148
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 3 h;
2: With water in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2009/10783 A1, 2009 ;
Location in patent: Page/Page column 59 ;
WO 2009/010783 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 3 h; Inert atmosphereReflux;
2: With water; potassium hydroxide in tetrahydrofuran
T=20°C;
参考文献
Tang, Yi-Qiang; Lu, Jian-Mei; Wang, Xiu-Ren; Shao, Li-Xiong
Tetrahedron, 2010 , vol. 66, # 40 p. 7970 - 7974
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C;
参考文献
Kobayashi; Inoue; Nishino; Fujihara; Oizumi; Kimura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 797 - 817
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
2 h; Heating;
参考文献
Chang, Meng-Yang; Chen, Chung-Yi; Tasi, Min-Ruey; Tseng, Tze-Wei; Chang, Nein-Chen
Synthesis, 2004 , # 6 p. 840 - 846
反应条件
1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C
1.2: tetrahydrofuran / 6 h / Heating
2.1: LiAlH4 / tetrahydrofuran / 2 h / Heating
3.1: Na(Hg); sodium phosphate / methanol / 2 h / 20 °C
4.1: LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Chang, Meng-Yang; Chen, Chung-Yi; Tasi, Min-Ruey; Tseng, Tze-Wei; Chang, Nein-Chen
Synthesis, 2004 , # 6 p. 840 - 846
反应条件
1: NaOH
2: 85 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
View Scheme
参考文献
Kurkin; Karchava; Yurovskaya
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 10 p. 1141 - 1148
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 24 h / 0 - 20 °C
2.1: dichloromethane / 4 h / 20 °C / Cooling with ice
3.1: potassium carbonate / acetonitrile / 0.25 h / 0 °C
3.2: 16 h / Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Cooling with ice
View Scheme
参考文献
Thompson, Scott Kevin; Priestley, Tony; Smith, Roger Astbury; Saha, Ashis K.; Rudra, Sonali; Hajra, Arun Kuma; Chatterjee, Dipanwita; Behrens, Carl Henry; He, Yigang; Li, Hui-Yin
Patent: US2012/214809 A1, 2012 ;
US 20120214809 A1
